Substance profile
P-Anisidine
P-Anisidine is a white solid with an amine-like odor.
01 · Identification
What P-Anisidine is
P-Anisidine is a white solid with an amine-like odor. Its molecular formula is C7H9NO and its molecular weight is 123.15 g/mol. It boils at 243 °C, melts at 57.2 °C, is soluble in water.
Under the GHS it carries the signal word Danger.
02 · Identifiers
P-Anisidine identifiers and molecular data
P-Anisidine CAS number and EC number
P-Anisidine molecular formula and molecular weight
Other names for P-Anisidine
- 4-methoxyaniline
03 · GHS classification
P-Anisidine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
P-Anisidine pictograms and signal word
P-Anisidine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 1 or 2 | H300 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 1 or 2 | H310 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 1 or 2 | H330 | GHS06 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 2 | H373 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
P-Anisidine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H310 | Fatal in contact with skin. |
| H330 | Fatal if inhaled. |
| H300 | Fatal if swallowed. |
| H373 | May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H400 | Very toxic to aquatic life. |
This page lists only the codes assigned to P-Anisidine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for P-Anisidine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of P-Anisidine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
P-Anisidine precautionary statements
CLP Annex VI assigns 14 precautionary statements to P-Anisidine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
P-Anisidine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | p -анизидин 4-метоксианилин |
| Spanish español | p -Anisidina 4-metoxianilina |
| Czech čeština | p -anisidin 4-methoxyanilin |
| Danish dansk | p -anisidin 4-methoxyanilin |
| German Deutsch | p -Anisidin 4-Methoxyanilin |
| Estonian eesti | p -anisidiin 4-metoksüaniliin |
| Greek ελληνικά | p -ανισιδίνη 4-μεθοξυανιλίνη |
| English English | p -anisidine 4-methoxyaniline |
| French français | p -anisidine 4-méthoxyaniline |
| Croatian hrvatski | p -anisidin 4-metoksianilin |
| Italian italiano | p -anisidina 4-metossianilina |
| Latvian latviešu | p -anizidīns 4-metoksianilīns |
| Lithuanian lietuvių | p -anizidinas 4-metoksianilinas |
| Hungarian magyar | p -anizidin 4-metoxianilin |
| Maltese Malti | p -anisidina 4-metossianilina |
| Dutch Nederlands | p -anisidine 4-methoxyaniline |
| Polish polski | p -anizydyna 4-metoksyanilina |
| Portuguese português | p -anisidina 4-metoxianilina |
| Romanian română | p -anisidină 4-metoxianilină |
| Slovak slovenčina | para -anizidín 4-metoxyanilín |
| Slovenian slovenščina | p -anizidin 4-metoksianilin |
| Finnish suomi | p -anisidiini 4-metoksianiliini |
| Swedish svenska | p -anisidin 4-metoxianilin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
P-Anisidine GHS label elements
Everything CLP Annex VI fixes for P-Anisidine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
P-Anisidine
- Fatal in contact with skin.
- Fatal if inhaled.
- Fatal if swallowed.
- May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Very toxic to aquatic life.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention if you feel unwell.
- Rinse mouth.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open P-Anisidine in the GHS label constructor →
07 · Health hazards
P-Anisidine health hazards and exposure limits
P-Anisidine hazard summary
Bladder cancer in animals observed in chronic feeding studies; Methemoglobinemia has been reported in exposed workers. Listed in the table Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity; [ACGIH] IARC classifies p-Anisidine as 3 (Not classifiable as to carcinogenicity to humans) and o-Anisidine as 2B (possibly carcinogenic to humans). A skin, eye, and respiratory tract irritant; Can induce methemoglobinemia; [ICSC]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
P-Anisidine carcinogenicity classification
No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
P-Anisidine occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 0.5 [mg/m3] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | TWA 0.5 mg/m3 [skin] | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | TWA 0.5 mg/m3 [skin] | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | 50 mg/m3 (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 50.0 [mg/m3] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| IDLH | 50 mg/cu m | Hazardous Substances Data Bank (HSDB) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
P-Anisidine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
P-Anisidine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 243 °C (469.4 °F) | HSDB | |
| 246.11 °C (475 °F) | NIOSH | ||
| 242.78 °C (469 °F) | at 760 mmHg | CAMEO |
P-Anisidine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 57.2 °C (135 °F) | HSDB | |
| 57.22 °C (135 °F) | NIOSH |
P-Anisidine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.07 g/cm³ | NIOSH | |
| 1.071 g/cm³ | at 57 °C | HSDB |
P-Anisidine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in acetone, benzene; very soluble in ether, ethanol | HSDB | |
| Moderate | NIOSH | ||
| In water, 2.10X10+4 mg/L at 20 °C | at 20 °C | HSDB |
P-Anisidine vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.03 mmHg | at 20 °C | HSDB |
| 0.015 mmHg | at 20 °C | ICSC | |
| 0.006 mmHg | at 25 °C | NIOSH |
P-Anisidine flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 122 °C (251.6 °F) | HSDB | |
| 5 °C (41 °F) | CAMEO |
P-Anisidine autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 515 °C (959 °F) | HSDB |
P-Anisidine lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Finely dispersed particles form explosive mixtures in air. | HSDB | |
| Combustible Solid | NIOSH |
P-Anisidine vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4.28 (air = 1) | HSDB | |
| 4.25 (air = 1) | CAMEO | ||
| 4.3 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
P-Anisidine fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
P-Anisidine fire potential
Combustible.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
P-Anisidine storage and handling
P-Anisidine safe storage
Separated from strong oxidants, strong bases, acids, chloroformates and food and feedstuffs. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
P-Anisidine storage conditions
Store in tightly closed containers in a cool, dark, well-ventilated area. Protect against sunlight and strong oxidizers. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition, such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. A regulated, marked area should be established where this chemical is handled, used, or stored ... /Anisidines/
Source: Hazardous Substances Data Bank (HSDB)
P-Anisidine incompatible materials
Incompatible with strong oxidizers, with risk of fire or explosions. Attacks some coatings and some forms of plastic and rubber. /Anisidines/
Source: Hazardous Substances Data Bank (HSDB)
P-Anisidine reactivity
P-ANISIDINE may be sensitive to heat, light and moisture. Reacts with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. Incompatible with alkaline materials. Incompatible with aldehydes, ketones and nitrates. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check P-Anisidine in the storage compatibility matrix →
11 · Questions
P-Anisidine — frequently asked questions
What is the CAS number of P-Anisidine?
The CAS number of P-Anisidine is 104-94-9. Its EC number is 203-254-2.
What is the chemical formula of P-Anisidine?
The molecular formula of P-Anisidine is C7H9NO and its molecular weight is 123.15 g/mol.
What does a P-Anisidine label have to show?
Under CLP Annex VI the label for P-Anisidine carries the pictograms Skull and crossbones, Health hazard and Environment and the signal word is Danger.
Is P-Anisidine flammable?
CLP Annex VI assigns P-Anisidine no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 122 °C (251.6 °F) (HSDB).
Is P-Anisidine a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for P-Anisidine. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health. IARC places it in Group 3: not classifiable as to its carcinogenicity to humans.
What is the exposure limit for P-Anisidine?
The US occupational exposure limit reported for P-Anisidine is 0.5 [mg/m3] (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of P-Anisidine?
The boiling point reported for P-Anisidine is 243 °C (469.4 °F) (HSDB).
What is the melting point of P-Anisidine?
The melting point reported for P-Anisidine is 57.2 °C (135 °F) (HSDB).
How should P-Anisidine be stored?
Store in tightly closed containers in a cool, dark, well-ventilated area. Protect against sunlight and strong oxidizers. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition, such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. A regulated, marked area should be established where this chemical is handled, used, or stored ... /Anisidines/ (Hazardous Substances Data Bank (HSDB))
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