Substance profile
Tetrahydrothiophene
Tetrahydrothiophene is a water-white liquid with a stench odor.
01 · Identification
What Tetrahydrothiophene is
Tetrahydrothiophene is a water-white liquid with a stench odor. Its molecular formula is C4H8S and its molecular weight is 88.17 g/mol. It boils at 121 °C, melts at -96.2 °C.
Under the GHS it carries the signal word Danger. It is classed as flammable agents - 3rd degree.
02 · Identifiers
Tetrahydrothiophene identifiers and molecular data
Tetrahydrothiophene CAS number and EC number
Tetrahydrothiophene molecular formula and molecular weight
03 · GHS classification
Tetrahydrothiophene hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Tetrahydrothiophene pictograms and signal word
Tetrahydrothiophene hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Flammable liquids GHS chapter 2.6 | Category 2 | H225 | GHS02 |
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 4 | H312 | GHS07 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 4 | H332 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 3 | H412 | — |
Tetrahydrothiophene hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H225 | Highly flammable liquid and vapour. |
| H332 | Harmful if inhaled. |
| H312 | Harmful in contact with skin. |
| H302 | Harmful if swallowed. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H412 | Harmful to aquatic life with long lasting effects. |
This page lists only the codes assigned to Tetrahydrothiophene. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Tetrahydrothiophene
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Tetrahydrothiophene issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Tetrahydrothiophene precautionary statements
CLP Annex VI assigns 23 precautionary statements to Tetrahydrothiophene. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Tetrahydrothiophene name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | тетрахидротиофен |
| Spanish español | Tetrahidrotiofeno |
| Czech čeština | tetrahydrothiofen |
| Danish dansk | tetrahydrothiophen |
| German Deutsch | Tetrahydrothiophen |
| Estonian eesti | tetrahüdrotiofeen |
| Greek ελληνικά | τετραϋδροθειοφαίνιο |
| English English | tetrahydrothiophene |
| French français | tétrahydrothiophène |
| Croatian hrvatski | tetrahidrotiofen |
| Italian italiano | tetraidrotiofene |
| Latvian latviešu | tetrahidrotiofēns |
| Lithuanian lietuvių | tetrahidrotiofenas |
| Hungarian magyar | tetrahidrotiofén |
| Maltese Malti | tetraidrotiofen |
| Dutch Nederlands | tetrahydrothiofeen |
| Polish polski | tetrahydrotiofen |
| Portuguese português | tetra-hidrotiofeno |
| Romanian română | tetrahidrotiofen |
| Slovak slovenčina | tetrahydrotiofén |
| Slovenian slovenščina | tetrahidrotiofen |
| Finnish suomi | tetrahydrotiofeeni |
| Swedish svenska | tetrahydrotiofen |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Tetrahydrothiophene GHS label elements
Everything CLP Annex VI fixes for Tetrahydrothiophene, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Tetrahydrothiophene
- Highly flammable liquid and vapour.
- Harmful if inhaled.
- Harmful in contact with skin.
- Harmful if swallowed.
- Causes skin irritation.
- Causes serious eye irritation.
- Harmful to aquatic life with long lasting effects.
- Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- Keep container tightly closed.
- Use explosion-proof [electrical/ventilating/lighting/…] equipment.
- Use only non-sparking tools.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF IN EYES:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
- Store in a well-ventilated place.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Tetrahydrothiophene in the GHS label constructor →
07 · Health hazards
Tetrahydrothiophene health hazards and exposure limits
Tetrahydrothiophene hazard summary
Not an eye irritant; Workers complained of nausea and headaches; [HSDB]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
Tetrahydrothiophene properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Tetrahydrothiophene boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 121.12 °C (250 °F) | at 760 mmHg | HSDB |
| 120 °C (248 °F) | range, midpoint shown | ICSC |
Tetrahydrothiophene melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -96.16 °C (-141.1 °F) | HSDB | |
| -96.2 °C (-141.2 °F) | ICSC |
Tetrahydrothiophene density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1 g/cm³ | ICSC | |
| 0.9987 g/cm³ | at 20 °C | HSDB |
Tetrahydrothiophene solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | INSOLUBLE IN WATER; SOL IN ALL PROPORTIONS IN ALCOHOL, ETHER, ACETONE, BENZENE, IN ORGANIC SOLVENTS | HSDB | |
| Solubility in water: none | ICSC |
Tetrahydrothiophene vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 18.0015 mmHg | at 25 °C | ICSC |
| 18.4 mmHg | Haz-Map |
Tetrahydrothiophene flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 12.78 °C (55 °F) | HSDB | |
| 12 °C (53.6 °F) | ICSC |
Tetrahydrothiophene autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 200 °C (392 °F) | ICSC |
Tetrahydrothiophene lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 1.1 % by volume | ICSC |
Tetrahydrothiophene upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 12.3 % by volume | ICSC |
Tetrahydrothiophene vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 3.05 (air = 1) | ICSC |
Tetrahydrothiophene odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | 1 part per billion | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Tetrahydrothiophene fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Tetrahydrothiophene fire potential
Flammable liquid
Source: Hazardous Substances Data Bank (HSDB)
Fire and explosion
THREE VIOLENT EXPLOSIONS OCCURRED WHILE OXIDIZING TETRAHYDROTHIOPHENE TO TETRAMETHYLENE SULFOXIDE WITH HYDROGEN PEROXIDE. FOR 10 YR SIMILAR OXIDATIONS WERE CARRIED OUT WITH NO EXPLOSIONS. THE THREE RUNS THAT EXPLODED WERE PROCEEDING NORMALLY UNTIL WHISPY WHITE SMOKE FORMED ABOVE THE LIQUID LAYER JUST PRIOR TO THE CONCUSSION.
Source: HSDB
10 · Handling and storage
Tetrahydrothiophene storage and handling
Tetrahydrothiophene safe storage
Fireproof. Separated from strong oxidants. Cool. Store in an area without drain or sewer access.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Tetrahydrothiophene reactivity
Organosulfides, such as TETRAHYDROTHIOPHENE, are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Slow addition of hydrogen peroxide to the thiophene resulted in explosions on three occasions, Chem. Eng. News, 1974, 52(39), 3.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Tetrahydrothiophene in the storage compatibility matrix →
11 · Transport
Tetrahydrothiophene UN number and transport classification
Transport classification is a separate system from the GHS classification above. It decides how a package is marked and how a load may be carried; it does not follow from the workplace label, and the workplace label does not follow from it. The entries below are linked by CAS number, never by name.
Tetrahydrothiophene under UN 2412 — shipping name, class and packing group
Europe · ADR 2025, Table A
| Proper shipping name (3.1.2) | Class | Classification code | PG | Labels (column 5) |
|---|---|---|---|---|
| TETRAHYDROTHIOPHENE | 3 | F1 | II | |
Source: ADR 2025, Table A of Chapter 3.2 · ECE/TRANS/352 Vol. I (UNECE). Class 3 is “Flammable liquids” (ADR 2.1.1.1).
United States · 49 CFR 172.101 Hazardous Materials Table
| Proper shipping name (column 2) | Class or division | PG | Labels (column 6) |
|---|---|---|---|
| Tetrahydrothiophene | 3 | II | |
Source: 49 CFR 172.101 Hazardous Materials Table · eCFR, revision 2026-08-03. Class 3 is “Flammable and combustible liquid” (49 CFR 173.2).
12 · Questions
Tetrahydrothiophene — frequently asked questions
What is the CAS number of Tetrahydrothiophene?
The CAS number of Tetrahydrothiophene is 110-01-0. Its EC number is 203-728-9.
What is the chemical formula of Tetrahydrothiophene?
The molecular formula of Tetrahydrothiophene is C4H8S and its molecular weight is 88.17 g/mol.
What does a Tetrahydrothiophene label have to show?
Under CLP Annex VI the label for Tetrahydrothiophene carries the pictograms Flame and Exclamation mark and the signal word is Danger.
Is Tetrahydrothiophene flammable?
Yes. CLP Annex VI assigns Tetrahydrothiophene H225 — highly flammable liquid and vapour. The flash point reported for it is 12.78 °C (55 °F) (HSDB).
Is Tetrahydrothiophene a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Tetrahydrothiophene. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Tetrahydrothiophene?
The boiling point reported for Tetrahydrothiophene is 121.12 °C (250 °F), at 760 mmHg (HSDB).
What is the melting point of Tetrahydrothiophene?
The melting point reported for Tetrahydrothiophene is -96.16 °C (-141.1 °F) (HSDB).
How should Tetrahydrothiophene be stored?
CLP Annex VI assigns Tetrahydrothiophene the storage statement P403.
Nearby
Substances next to Tetrahydrothiophene
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