Substance profile
Theophylline
Theophylline is a white, crystalline alkaloid and is odorless.
01 · Identification
What Theophylline is
Theophylline is a white, crystalline alkaloid and is odorless. Its molecular formula is C7H8N4O2 and its molecular weight is 180.16 g/mol. It melts at 274 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Theophylline identifiers and molecular data
Theophylline CAS number and EC number
Theophylline molecular formula and molecular weight
Other names for Theophylline
- 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
03 · GHS classification
Theophylline hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Theophylline pictograms and signal word
Theophylline hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H360D | May damage the unborn child. |
This page lists only the codes assigned to Theophylline. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Theophylline
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Theophylline issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Theophylline precautionary statements
CLP Annex VI assigns 4 precautionary statements to Theophylline. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Theophylline name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | теофилин 1,3-диметил-3,7-дихидро-1 Н -пурин-2,6-дион |
| Spanish español | Teofilina 1,3-dimetil-3,7-dihidro-1 H -purina-2,6-diona |
| Czech čeština | theofylin 1,3-dimethyl-3,7-dihydro-1 H -purin-2,6-dion |
| Danish dansk | theophyllin 1,3-dimethyl-3,7-dihydro-1 H -purin-2,6-dion |
| German Deutsch | Theophyllin 1,3-Dimethyl-3,7-dihydro-1 H -purin-2,6-dion |
| Estonian eesti | teofülliin 3,7-dihüdro-1,3-dimetüül-1 H -puriin-2,6-dioon |
| Greek ελληνικά | θεοφυλλίνη 1,3- διμεθυλο-3,7-διυδρο-1 H -πουρινο-2,6-διόνη |
| English English | theophylline 1,3-dimethyl-3,7-dihydro-1 H -purine-2,6-dione |
| French français | théophylline 1,3-diméthyl-3,7-dihydro-1 H -purine-2,6-dione |
| Croatian hrvatski | teofilin 1,3-dimetil-3,7-dihidro-1 H -purin-2,6-dion |
| Italian italiano | teofillina 1,3-dimetil-3,7-diidro-1H-purina-2,6-dione |
| Latvian latviešu | teofilīns 1,3-dimetil-3,7-dihidro-1 H -purīn-2,6-dions |
| Lithuanian lietuvių | teofilinas 1,3-dimetil-3,7-dihidro-1 H -purin-2,6-dionas |
| Hungarian magyar | teofillin 1,3-dimetil-3,7-dihidro-1 H -purin-2,6-dion |
| Maltese Malti | teofillina 1,3-dimetil-3,7-diidro-1 H -purina-2,6-dion |
| Dutch Nederlands | theofylline 1,3-dimethyl-3,7-dihydro-1 H -purine-2,6-dion |
| Polish polski | teofilina 3,7-Dihydro-1,3-dimetylo-1 H -puryno-2,6-dion |
| Portuguese português | teofilina 1,3-dimetil-3,7-di-hidro-1 H -purina-2,6-diona |
| Romanian română | teofilină 1,3-dimetil-3,7-dihidro-1 H -purina-2,6-dionă |
| Slovak slovenčina | teofilină 1,3-dimetil-3,7-dihidro-1 H -purina-2,6-dionă |
| Slovenian slovenščina | teofilin 1,3-dimetil-3,7-dihidro-1 H -purin-2,6-dion |
| Finnish suomi | teofylliini 1,3-dimetyyli-3,7-dihydro-1 H -puriini-2,6-dioni |
| Swedish svenska | teofyllin 1,3-dimetyl-3,7-dihydro-1 H -purin-2,6-dion |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Theophylline GHS label elements
Everything CLP Annex VI fixes for Theophylline, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Theophylline
- May damage the unborn child.
- Obtain special instructions before use.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF exposed or concerned:
- Get medical advice/attention.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Theophylline in the GHS label constructor →
07 · Health hazards
Theophylline health hazards and exposure limits
Theophylline carcinogenicity classification
Under the conditions of these 2-year gavage studies, there was no evidence of carcinogenic activity of theophylline in male or female F344/N rats administered 7.5, 25, or 75 mg/kg. There was no evidence of carcinogenic activity of theophylline in male B6C3F1 mice administered 15, 50, or 150 mg/kg or female B6C3F1 mice administered 7.5, 25, or 75 mg/kg.
Source: US National Toxicology Program · TR-473: Toxicology and Carcinogenesis Studies of Theophylline in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies) (1998 )
Evaluation: There is inadequate evidence for the carcinogenicity in humans of theophylline. There is inadequate evidence for the carcinogenicity in experimental animals of theophylline. Overall evaluation: Theophylline is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Theophylline properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Theophylline melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 274 °C (525.2 °F) | HSDB | |
| 273.06 °C (523.5 °F) | range, midpoint shown | CAMEO | |
| 272 °C (521.6 °F) | range, midpoint shown | ICSC |
Theophylline density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | g/cm³ | ICSC |
Theophylline solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Slightly soluble in water | HSDB | |
| Slightly soluble in ethanol, ether, chloroform | HSDB | ||
| In water, 7,360 mg/L at 25 °C | at 25 °C | HSDB |
Theophylline vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | negligible | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
Theophylline storage and handling
Theophylline safe storage
Separated from food and feedstuffs.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Theophylline storage conditions
Store at 20 deg -25 °C (68 deg - 77 °F); excursions permitted between 15 deg - 30 °C (59 deg - 86 °F).
Source: Hazardous Substances Data Bank (HSDB)
Theophylline incompatible materials
Incompatible materials: Strong oxidizing agents.
Source: Hazardous Substances Data Bank (HSDB)
Theophylline reactivity
THEOPHYLLINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Theophylline in the storage compatibility matrix →
10 · Questions
Theophylline — frequently asked questions
What is the CAS number of Theophylline?
The CAS number of Theophylline is 58-55-9. Its EC number is 200-385-7.
What is the chemical formula of Theophylline?
The molecular formula of Theophylline is C7H8N4O2 and its molecular weight is 180.16 g/mol.
What does a Theophylline label have to show?
Under CLP Annex VI the label for Theophylline carries the pictogram Health hazard and the signal word is Danger.
Is Theophylline flammable?
CLP Annex VI assigns Theophylline no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Theophylline a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Theophylline. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health. IARC places it in Group 3: not classifiable as to its carcinogenicity to humans.
What is the melting point of Theophylline?
The melting point reported for Theophylline is 274 °C (525.2 °F) (HSDB).
How should Theophylline be stored?
Store at 20 deg -25 °C (68 deg - 77 °F); excursions permitted between 15 deg - 30 °C (59 deg - 86 °F). (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Theophylline
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