Substance profile
Thiram
Thiram is a white crystalline powder with a characteristic odor.
01 · Identification
What Thiram is
Thiram is a white crystalline powder with a characteristic odor. Its molecular formula is C6H12N2S4 and its molecular weight is 240.4 g/mol. It melts at 146 °C.
Under the GHS it carries the signal word Warning. It is classed as mutagens.
02 · Identifiers
Thiram identifiers and molecular data
Thiram CAS number and EC number
Thiram molecular formula and molecular weight
Other names for Thiram
- thiram (ISO)
- tetramethylthiuram disulphide
03 · GHS classification
Thiram hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Thiram pictograms and signal word
Thiram hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 4 | H332 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 2 | H373 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Thiram hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H332 | Harmful if inhaled. |
| H302 | Harmful if swallowed. |
| H373 | May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H317 | May cause an allergic skin reaction. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Thiram. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Thiram
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Thiram issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Thiram precautionary statements
CLP Annex VI assigns 23 precautionary statements to Thiram. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Thiram name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | тирам (ISO) тетраметилтиурам дисулфид |
| Spanish español | Tiram (ISO) disulfuro de tetrametiltiuram |
| Czech čeština | thiram (ISO) bis(dimethylthiokarbamoyl)disulfid |
| Danish dansk | thiram (ISO) tetramethylthiuramdisulfid |
| German Deutsch | Thiram (ISO) TetramethylthiuramdisulfidBis(dimethyl-thiocarbamoyl)-disulfid |
| Estonian eesti | tiraam (ISO) tetrametüültiuraamdisulfiid |
| Greek ελληνικά | thiram (θιράμη) (ISO) δισουλφίδιo της τετραμεθυλοθειoυράμης |
| English English | thiram (ISO) tetramethylthiuram disulphide |
| French français | thirame (ISO) disulfure de tétraméthylthiurame |
| Croatian hrvatski | tiram (ISO) tetrametil-tiuram disulfid |
| Italian italiano | tiram (bis dimetilcarbamoil) disolfuro |
| Latvian latviešu | tirams (ISO) tetrametiltiurama disulfīds |
| Lithuanian lietuvių | tiramas (ISO) tetrametiltiuramo disulfidas |
| Hungarian magyar | tiram (ISO) tetrametiltiuram-diszulfid |
| Maltese Malti | tiram (ISO) disulfur tat-tetrametiltjuram |
| Dutch Nederlands | thiram (ISO) tetramethylthiuramdisulfide |
| Polish polski | tiuram (ISO) disulfid tetrametylotiuramu |
| Portuguese português | tirame (ISO) dissulfureto de tetrametiltiurame |
| Romanian română | tiram (ISO) disulfură de tetrametiltiuram |
| Slovak slovenčina | tirám (ISO) bis(dimetyltiokarbamoyl)disulfán |
| Slovenian slovenščina | tiram (ISO) tetrametiltiuram disulfid |
| Finnish suomi | tiraami (ISO) tetrametyylitiuraamidisulfidi |
| Swedish svenska | tiram (ISO) tetrametyltiuramdisulfid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Thiram GHS label elements
Everything CLP Annex VI fixes for Thiram, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Thiram
- Harmful if inhaled.
- Harmful if swallowed.
- May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Causes skin irritation.
- Causes serious eye irritation.
- May cause an allergic skin reaction.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF IN EYES:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Get medical advice/attention if you feel unwell.
- Rinse mouth.
- If skin irritation occurs:
- If skin irritation or rash occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Thiram in the GHS label constructor →
07 · Health hazards
Thiram health hazards and exposure limits
Thiram hazard summary
An irritant and a skin sensitizer, thiram is classified as slightly toxic. [EXTOXNET] No increased tumors in chronic studies of rodents; Reproductive endpoints are not generally altered and the fetal animal does not appear to be more sensitive. [ACGIH] The EBCDCs (ethylenebisdithiocarbamates) can cause irritant and allergic contact dermatitis. EBDCs include ferbam, vapam, maneb, mancozeb, zineb, thiram, and ziram. They are also used as rubber accelerators. Ethylene thiourea (ETU), which may contaminate EBCDCs, is carcinogenic and teratogenic in animal experiments. [LaDou, p. 610] ETU is the major metabolite of EBDCs. [Krieger, p. 1690] See the agent, Ethylene thiourea.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Thiram carcinogenicity classification
Cancer Classification: Not Likely to be Carcinogenic to Humans
Source: Hazardous Substances Data Bank (HSDB)
Evaluation: There is inadequate evidence in humans for the carcinogenicity of thiram. There is inadequate evidence for the carcinogenicity of thiram in experimental animals. Overall evaluation: Thiram is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
Thiram occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 5.0 [mg/m3] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | 5 mg/m³ | Occupational Safety and Health Administration (OSHA) |
| PEL | TWA 5 mg/m3 | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 5 mg/m³ | Occupational Safety and Health Administration (OSHA) |
| REL | TWA 5 mg/m3 | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | 100 mg/m3 (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 100.0 [mg/m3] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| IDLH | 100 mg/cu m | Hazardous Substances Data Bank (HSDB) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Thiram properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Thiram boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 129 °C (264.2 °F) | at 20 mmHg (reduced pressure) | HSDB |
| 128.89 °C (264 °F) | at 20 mmHg (reduced pressure) | CAMEO | |
| 129 °C (264.2 °F) | at 19.5016 mmHg (reduced pressure) | ICSC |
Thiram melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 146 °C (294.8 °F) | Commercial grade | HSDB |
| 155.56 °C (312 °F) | NIOSH |
Thiram density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.3 g/cm³ | HSDB | |
| 1.29 g/cm³ | NIOSH | ||
| 1.43 g/cm³ | at 20 °C | CAMEO |
Thiram solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Solubility in alcohol and in ether less than 0.2%; solubility in acetone 1.2%; in benzene 2.5%. | HSDB | |
| Sol in carbon disulfide | HSDB |
Thiram vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.000008 mmHg | NIOSH | |
| 0 mmHg | at 20 °C | CAMEO | |
| 0.0000172 mmHg | at 25 °C | HSDB |
Thiram flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 89 °C (192.2 °F) | HSDB | |
| 137.78 °C (280 °F) | CAMEO |
Thiram lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Combustible Solid | NIOSH |
Thiram odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | 5 mg/cu m | HSDB |
Thiram corrosivity
| Property | Value | Conditions | Source |
|---|---|---|---|
| Corrosivity | Non-corrosive in the dry state. | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Source notes
Further notes on Thiram
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Solubility
Solubility in ethanol <10 g/L at 25 °C, acetone 80 g/L at 25 °C, chloroform 230 g/L at 25 °C, hexane 0.04 g/L at 20 °C; dichloromethane 170 g/L at 20 °C, toluene 18 g/L at 20 °C, isopropanol 0.7 g/L at 20 °C.
Source: HSDB
10 · Handling and storage
Thiram storage and handling
Thiram safe storage
Separated from acids, strong oxidants and food and feedstuffs. Dry. Keep in a well-ventilated room.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Thiram storage conditions
Keep out of reach of children. Keep away from food, drink and animal feeding stuffs.
Source: Hazardous Substances Data Bank (HSDB)
Thiram incompatible materials
Strong oxidizers, strong acids, oxidizable materials.
Source: Hazardous Substances Data Bank (HSDB)
Thiram reactivity
THIRAM is incompatible with oxidizing materials and strong acids. Also incompatible with strong alkalis and nitrating agents (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Thiram in the storage compatibility matrix →
11 · Questions
Thiram — frequently asked questions
What is the CAS number of Thiram?
The CAS number of Thiram is 137-26-8. Its EC number is 205-286-2.
What is the chemical formula of Thiram?
The molecular formula of Thiram is C6H12N2S4 and its molecular weight is 240.4 g/mol.
What does a Thiram label have to show?
Under CLP Annex VI the label for Thiram carries the pictograms Health hazard, Exclamation mark and Environment and the signal word is Warning.
Is Thiram flammable?
CLP Annex VI assigns Thiram no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 89 °C (192.2 °F) (HSDB).
Is Thiram a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Thiram. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health. IARC places it in Group 3: not classifiable as to its carcinogenicity to humans.
What is the exposure limit for Thiram?
The US occupational exposure limit reported for Thiram is 5.0 [mg/m3] (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Thiram?
The boiling point reported for Thiram is 129 °C (264.2 °F), at 20 mmHg (reduced pressure) (HSDB).
What is the melting point of Thiram?
The melting point reported for Thiram is 146 °C (294.8 °F), Commercial grade (HSDB).
How should Thiram be stored?
Keep out of reach of children. Keep away from food, drink and animal feeding stuffs. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Thiram
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