Substance profile
Tris(2-chloroethyl) phosphate
Tris(2-chloroethyl) phosphate is a clear, transparent liquid with a low odor.
01 · Identification
What Tris(2-chloroethyl) phosphate is
Tris(2-chloroethyl) phosphate is a clear, transparent liquid with a low odor. Its molecular formula is C6H12Cl3O4P and its molecular weight is 285.5 g/mol. It boils at 330 °C, melts at -55 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Tris(2-chloroethyl) phosphate identifiers and molecular data
Tris(2-chloroethyl) phosphate CAS number and EC number
Tris(2-chloroethyl) phosphate molecular formula and molecular weight
Other names for Tris(2-chloroethyl) phosphate
- tris(2-chloroethyl)phosphate
03 · GHS classification
Tris(2-chloroethyl) phosphate hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Tris(2-chloroethyl) phosphate pictograms and signal word
Tris(2-chloroethyl) phosphate hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 2 | H351 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 2 | H411 | GHS09 |
Tris(2-chloroethyl) phosphate hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H351 | Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H360F | May damage fertility. |
| H302 | Harmful if swallowed. |
| H411 | Toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Tris(2-chloroethyl)…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Tris(2-chloroethyl)…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Tris(2-chloroethyl)… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Tris(2-chloroethyl) phosphate precautionary statements
CLP Annex VI assigns 11 precautionary statements to Tris(2-chloroethyl)…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Tris(2-chloroethyl) phosphate name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | трис(2-хлороетил)фосфат |
| Spanish español | Fosfato de tris(2-cloroetilo) |
| Czech čeština | tris(2-chlorethyl)-fosfát |
| Danish dansk | tris(2-chlorethyl)phosphat |
| German Deutsch | Tris(2-chlorethyl)phosphat |
| Estonian eesti | tris(2-kloroetüül)fosfaat |
| Greek ελληνικά | φωσφορικός τρις(2-χλωροαιθυλ)εστέρας |
| English English | tris(2-chloroethyl)phosphate |
| French français | tris(2-chloroéthyl)phosphate |
| Croatian hrvatski | tris(2-kloretil)-fosfat |
| Italian italiano | fosfato di tris(2-cloroetile) |
| Latvian latviešu | tris(2-hloretil)fosfāts |
| Lithuanian lietuvių | tris(2-chloretil)fosfatas |
| Hungarian magyar | trisz(2-klóretil)foszfát |
| Maltese Malti | tris(2-kloroetil)fosfat |
| Dutch Nederlands | tris(2-chloorethyl)fosfaat |
| Polish polski | fosforan(V) tris(2-chloroetylu) |
| Portuguese português | fosfato de tris(2-cloroetilo) |
| Romanian română | fosfat de tris(2-cloroetil) |
| Slovak slovenčina | tris(2-chlóretyl)-fosfát |
| Slovenian slovenščina | tris(2-kloroetil)fosfat |
| Finnish suomi | tris(2-kloorietyyli)fosfaatti |
| Swedish svenska | tris(2-kloretyl)fosfat |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Tris(2-chloroethyl) phosphate GHS label elements
Everything CLP Annex VI fixes for Tris(2-chloroethyl)…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Tris(2-chloroethyl) phosphate
- Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May damage fertility.
- Harmful if swallowed.
- Toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Tris(2-chloroethyl)… in the GHS label constructor →
07 · Health hazards
Tris(2-chloroethyl) phosphate health hazards and exposure limits
Tris(2-chloroethyl) phosphate hazard summary
Causes slight eye irritation; Skin absorption is minimal; In high dose animal studies, findings include testicular damage, some inhibition of cholinesterase, and central nervous system effects including seizures. CNS effects may be due to cholinesterase inhibition or direct toxicity to brain. [HSDB] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Tris(2-chloroethyl) phosphate carcinogenicity classification
Under the conditions of these 2-year gavage studies, there was clear evidence of carcinogenic activity for male and female F344/N rats receiving tris(2-chloroethyl)phosphate as shown by increased incidences of renal tubule adenomas. Thyroid follicular cell neoplasms and mononuclear cell leukemia in male and female rats may have been related to chemical administration. There was equivocal evidence of carcinogenic activity for male B6C3F1 mice as shown by a marginally increased incidence of renal tubule cell neoplasms. There was equivocal evidence of carcinogenic activity for female B6C3F1 mice as shown by a marginally increased incidence of harderian gland adenomas.
Source: US National Toxicology Program · TR-391: Toxicology and Carcinogenesis Studies of Tris(2-chloroethyl) Phosphate (CASRN 115-96-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1991 )
Evaluation: No epidemiological data relevant to the carcinogenicity of tris(2-chloroethyl)phosphate were available. There is limited evidence for the carcinogenicity of tris(2-chloroethyl)phosphate in experimental animals. Overall evaluation: Tris(2-chloroethyl)phosphate is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Tris(2-chloroethyl) phosphate properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Tris(2-chloroethyl) phosphate boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 330 °C (626 °F) | HSDB | |
| 330 °C (626 °F) | at 760 mmHg | CAMEO |
Tris(2-chloroethyl) phosphate melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -55 °C (-67 °F) | HSDB | |
| -51 °C (-59.8 °F) | ICSC |
Tris(2-chloroethyl) phosphate density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.4 g/cm³ | ICSC | |
| 1.425 g/cm³ | at 20 °C | CAMEO | |
| 1.39 g/cm³ | at 25 °C | HSDB |
Tris(2-chloroethyl) phosphate solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | In water, 7,000 mg/L, temp not specified. | HSDB | |
| Insoluble in benzene. Soluble in most organic solvents. | HSDB | ||
| In water, 7.82X10+3 mg/L at 20 °C | at 20 °C | HSDB |
Tris(2-chloroethyl) phosphate vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.000016 mmHg | at 25 °C | HSDB |
| 0.0613 mmHg | at 25 °C | HSDB | |
| 0.5 mmHg | at 145 °C | HSDB |
Tris(2-chloroethyl) phosphate flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 216 °C (420.8 °F) | Cleveland open cup | HSDB |
| 232 °C (449.6 °F) | HSDB | ||
| 232.22 °C (450 °F) | CAMEO |
Tris(2-chloroethyl) phosphate autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 601.67 °C (1115 °F) | HSDB | |
| 480 °C (896 °F) | ICSC |
Tris(2-chloroethyl) phosphate vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 9.8 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Tris(2-chloroethyl)… fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Tris(2-chloroethyl) phosphate fire potential
Combustible when exposed to heat or flame.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Tris(2-chloroethyl) phosphate storage and handling
Tris(2-chloroethyl) phosphate safe storage
Keep in a well-ventilated room. Store in an area without drain or sewer access. Separated from food and feedstuffs. Provision to contain effluent from fire extinguishing.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Tris(2-chloroethyl) phosphate storage conditions
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Source: Hazardous Substances Data Bank (HSDB)
Tris(2-chloroethyl) phosphate incompatible materials
Reacts with strong bases and strong oxidants.
Source: Hazardous Substances Data Bank (HSDB)
Tris(2-chloroethyl) phosphate reactivity
TRIS(2-CHLOROETHYL) PHOSPHATE is incompatible with strong oxidizing agents and strong bases. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Tris(2-chloroethyl)… in the storage compatibility matrix →
11 · Questions
Tris(2-chloroethyl) phosphate — frequently asked questions
What is the CAS number of Tris(2-chloroethyl) phosphate?
The CAS number of Tris(2-chloroethyl) phosphate is 115-96-8. Its EC number is 204-118-5.
What is the chemical formula of Tris(2-chloroethyl) phosphate?
The molecular formula of Tris(2-chloroethyl) phosphate is C6H12Cl3O4P and its molecular weight is 285.5 g/mol.
What does a Tris(2-chloroethyl) phosphate label have to show?
Under CLP Annex VI the label for Tris(2-chloroethyl) phosphate carries the pictograms Health hazard, Exclamation mark and Environment and the signal word is Danger.
Is Tris(2-chloroethyl) phosphate flammable?
CLP Annex VI assigns Tris(2-chloroethyl) phosphate no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 216 °C (420.8 °F), Cleveland open cup (HSDB).
Is Tris(2-chloroethyl) phosphate a carcinogen?
CLP Annex VI assigns Tris(2-chloroethyl) phosphate H351 — suspected of causing cancer. That is category 2: the evidence points that way but is not conclusive. IARC places it in Group 3: not classifiable as to its carcinogenicity to humans.
What is the boiling point of Tris(2-chloroethyl) phosphate?
The boiling point reported for Tris(2-chloroethyl) phosphate is 330 °C (626 °F) (HSDB).
What is the melting point of Tris(2-chloroethyl) phosphate?
The melting point reported for Tris(2-chloroethyl) phosphate is -55 °C (-67 °F) (HSDB).
How should Tris(2-chloroethyl) phosphate be stored?
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. (Hazardous Substances Data Bank (HSDB))
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