Substance profile
1,2-Dimethylhydrazine
1,2-Dimethylhydrazine is a clear, colorless liq with a fishy, ammonia odor.
01 · Identification
What 1,2-Dimethylhydrazine is
1,2-Dimethylhydrazine is a clear, colorless liq with a fishy, ammonia odor. Its molecular formula is C2H8N2 and its molecular weight is 60.1 g/mol. It boils at 81 °C, melts at -9 °C, is miscible with water.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
1,2-Dimethylhydrazine identifiers and molecular data
1,2-Dimethylhydrazine CAS number and EC number
1,2-Dimethylhydrazine molecular formula and molecular weight
03 · GHS classification
1,2-Dimethylhydrazine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
1,2-Dimethylhydrazine pictograms and signal word
1,2-Dimethylhydrazine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 3 | H331 | GHS06 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 2 | H411 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
1,2-Dimethylhydrazine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H331 | Toxic if inhaled. |
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
| H411 | Toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 1,2-Dimethylhydrazine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 1,2-Dimethylhydrazine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 1,2-Dimethylhydrazine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
1,2-Dimethylhydrazine precautionary statements
CLP Annex VI assigns 16 precautionary statements to 1,2-Dimethylhydrazine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
1,2-Dimethylhydrazine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 1,2-диметилхидразин |
| Spanish español | 1,2-Dimetilhidrazina |
| Czech čeština | N, N '-dimethylhydrazin |
| Danish dansk | 1,2-dimethylhydrazin |
| German Deutsch | 1,2-Dimethylhydrazin |
| Estonian eesti | 1,2-dimetüülhüdrasiin |
| Greek ελληνικά | 1,2-διμεθυλυδραζίνη |
| English English | 1,2-dimethylhydrazine |
| French français | 1,2-diméthylhydrazine |
| Croatian hrvatski | 1,2-dimetil-hidrazin |
| Italian italiano | 1,2-dimetilidrazina |
| Latvian latviešu | 1,2-dimetilhidrazīns |
| Lithuanian lietuvių | 1,2-dimetilhidrazinas |
| Hungarian magyar | 1,2-dimetilhidrazin |
| Maltese Malti | 1,2-dimetilidrażina |
| Dutch Nederlands | 1,2-dimethylhydrazine |
| Polish polski | 1,2-dimetylohydrazyna |
| Portuguese português | 1,2-dimetil-hidrazina |
| Romanian română | 1,2-dimetilhidrazină |
| Slovak slovenčina | 1,2-dimetylhydrazín |
| Slovenian slovenščina | 1,2-dimetilhidrazin |
| Finnish suomi | 1,2-dimetyylihydratsiini |
| Swedish svenska | 1,2-dimetylhydrazin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
1,2-Dimethylhydrazine GHS label elements
Everything CLP Annex VI fixes for 1,2-Dimethylhydrazine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
1,2-Dimethylhydrazine
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Toxic if inhaled.
- Toxic in contact with skin.
- Toxic if swallowed.
- Toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF exposed or concerned:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Rinse mouth.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 1,2-Dimethylhydrazine in the GHS label constructor →
07 · Health hazards
1,2-Dimethylhydrazine health hazards and exposure limits
1,2-Dimethylhydrazine hazard summary
Liquid causes second or third degree burns after short contact; [CHRIS] Patients poisoned by hydrazines may develop methemoglobinemia and liver injury; Emergency treatment: Hydrazines; [HSDB] Inhalation of hydrazine compounds in high concentrations can induce seizures and coma; Corrosive to skin; [Merck Index] Toxic after absorption through skin; Inhalation of high concentrations can induce pulmonary irritation and edema; [CAMEO] A strong reducing agent; An eye and respiratory tract irritant; May injure liver; Can be absorbed through skin; The kidney is target organ in experimental animals; [ICSC] Danger of skin sensitization; [MAK] Causes convulsions and dyspnea in lethal-dose inhalation studies of rats; [RTECS]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
1,2-Dimethylhydrazine carcinogenicity classification
Evaluation: No epidemiological data relevant to the carcinogenicity of 1,2-dimethylhydrazine were available. There is sufficient evidence in experimental animals for the carcinogenicity of 1,2-dimethylhydrazine. Overall evaluation: 1,2-Dimethylhydrazine is probably carcinogenic to humans (Group 2A). In making the overall evaluation, the Working Group took into account that 1,2-dimethylhydrazine is consistently mutagenic in a wide range of test systems and gives rise to a similar pattern of DNA damage in human and animal tissues in vitro.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
1,2-Dimethylhydrazine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
1,2-Dimethylhydrazine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 81 °C (177.8 °F) | at 753 mmHg | HSDB |
| 81 °C (177.8 °F) | at 760 mmHg | CAMEO | |
| 81 °C (177.8 °F) | ICSC |
1,2-Dimethylhydrazine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -9 °C (15.8 °F) | HSDB | |
| -8.9 °C (16 °F) | DOE PAC |
1,2-Dimethylhydrazine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 0.83 g/cm³ | ICSC | |
| 0.8274 g/cm³ | at 20 °C | HSDB |
1,2-Dimethylhydrazine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Miscible with alcohol, ether, dimethylformamide, hydrocarbons | HSDB | |
| Miscible with water: 1X10+6 mg/l at 25 °C | at 25 °C | HSDB | |
| Solubility in water, g/100ml at 25 °C: 100 | at 25 °C | ICSC |
1,2-Dimethylhydrazine vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 69.9 mmHg | at 25 °C | HSDB |
| 67.5056 mmHg | at 25 °C | ICSC | |
| 75 mmHg | at 26.4 °C | DOE PAC |
1,2-Dimethylhydrazine flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 23 °C (73.4 °F) | below this value, Closed cup | HSDB |
| -15 °C (5 °F) | Haz-Map |
1,2-Dimethylhydrazine lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 2.4 % by volume | ICSC |
1,2-Dimethylhydrazine upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 20 % by volume | ICSC |
1,2-Dimethylhydrazine vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 2.07 (air = 1) | ICSC |
1,2-Dimethylhydrazine corrosivity
| Property | Value | Conditions | Source |
|---|---|---|---|
| Corrosivity | Corrosive to skin | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
1,2-Dimethylhydrazine fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
1,2-Dimethylhydrazine fire potential
Flammable
Source: Hazardous Substances Data Bank (HSDB)
Odor
The warning properties (irritation & odor) of the hydrazines are probably sufficient to prevent acute poisoning from short exposures. However, in view of the chronic toxicity properties, the warning properties should not be considered adequate for prolonged exposures. /Hydrazines/
Source: HSDB
10 · Handling and storage
1,2-Dimethylhydrazine storage and handling
1,2-Dimethylhydrazine safe storage
Fireproof. Separated from strong oxidants. Well closed. Store in an area without drain or sewer access.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
1,2-Dimethylhydrazine storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
1,2-Dimethylhydrazine incompatible materials
Miscible with water with much evolution of heat.
Source: Hazardous Substances Data Bank (HSDB)
1,2-Dimethylhydrazine reactivity
1,2-DIMETHYLHYDRAZINE dissolves, swells, and disintegrates many plastics (USCG, 1999). It is a strong reducing agent and may react with oxidizing agents to generate heat and products that may be flammable, combustible, or otherwise reactive.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 1,2-Dimethylhydrazine in the storage compatibility matrix →
11 · Questions
1,2-Dimethylhydrazine — frequently asked questions
What is the CAS number of 1,2-Dimethylhydrazine?
The CAS number of 1,2-Dimethylhydrazine is 540-73-8.
What is the chemical formula of 1,2-Dimethylhydrazine?
The molecular formula of 1,2-Dimethylhydrazine is C2H8N2 and its molecular weight is 60.1 g/mol.
What does a 1,2-Dimethylhydrazine label have to show?
Under CLP Annex VI the label for 1,2-Dimethylhydrazine carries the pictograms Skull and crossbones, Health hazard and Environment and the signal word is Danger.
Is 1,2-Dimethylhydrazine flammable?
CLP Annex VI assigns 1,2-Dimethylhydrazine no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 23 °C (73.4 °F), below this value, Closed cup (HSDB).
Is 1,2-Dimethylhydrazine a carcinogen?
Yes. CLP Annex VI classifies 1,2-Dimethylhydrazine as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2A: probably carcinogenic to humans.
What is the boiling point of 1,2-Dimethylhydrazine?
The boiling point reported for 1,2-Dimethylhydrazine is 81 °C (177.8 °F), at 753 mmHg (HSDB).
What is the melting point of 1,2-Dimethylhydrazine?
The melting point reported for 1,2-Dimethylhydrazine is -9 °C (15.8 °F) (HSDB).
How should 1,2-Dimethylhydrazine be stored?
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ (Hazardous Substances Data Bank (HSDB))
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