Substance profile
2,2'-methylenebis-(3,4,6-trichlorophenol)
2,2'-methylenebis-(3,4,6-trichlorophenol) is crystals from benzene and is odorless.
01 · Identification
What 2,2'-methylenebis-(3,4,6-trich… is
2,2'-methylenebis-(3,4,6-trichlorophenol) is crystals from benzene and is odorless. Its molecular formula is C13H6Cl6O2 and its molecular weight is 406.9 g/mol. It boils at 167 °C, melts at 166 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
2,2'-methylenebis-(3,4,6-trich… identifiers and molecular data
2,2'-methylenebis-(3,4,6-trich… CAS number and EC number
2,2'-methylenebis-(3,4,6-trich… molecular formula and molecular weight
Other names for 2,2'-methylenebis-(3,4,6-trich…
- hexachlorophene
03 · GHS classification
2,2'-methylenebis-(3,4,6-trich… hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
2,2'-methylenebis-(3,4,6-trich… pictograms and signal word
2,2'-methylenebis-(3,4,6-trich… hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
2,2'-methylenebis-(3,4,6-trich… hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 2,2'-methylenebis-(3,4,6-t…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 2,2'-methylenebis-(3,4,6-t…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 2,2'-methylenebis-(3,4… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
2,2'-methylenebis-(3,4,6-trich… precautionary statements
CLP Annex VI assigns 10 precautionary statements to 2,2'-methylenebis-(3,4,6-t…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
2,2'-methylenebis-(3,4,6-trich… name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 2,2′-метиленбис(3,4,6-трихлорофенол) хексахлорофен |
| Spanish español | 2,2'-Metilen-bis-(3,4,6-triclorofenol) hexaclorofeno |
| Czech čeština | 3,3',4,4',6,6'-hexachlor-2,2'-methylendianilin hexachlorfen |
| Danish dansk | 2,2'-methylen-bis-(3,4,6-trichlorphenol) hexachlorophen |
| German Deutsch | 2,2'-Methylenbis(3,4,6-trichlorphenol) Hexachlorophen |
| Estonian eesti | 2,2'-metüleenbis(3,4,6-triklorofenool) heksaklorofeen |
| Greek ελληνικά | 2,2′-μεθυλενο-δις(3,4,6-τριχλωροφαινόλη) εξαχλωροφαίνιο |
| English English | 2,2'-methylenebis-(3,4,6-trichlorophenol) hexachlorophene |
| French français | 2,2'-méthylènebis-(3,4,6-trichlorophénol) hexachlorophène |
| Croatian hrvatski | 2,2'-metilenbis-(3,4,6-triklorfenol) heksaklorofen |
| Italian italiano | 2,2'-metilen-bis-(3,4,6-triclorofenolo) esaclorofene |
| Latvian latviešu | 2,2′-metilēnbis-(3,4,6-trihlorfenols) heksahlorofēns |
| Lithuanian lietuvių | 2,2'-metilen-bis-(3,4,6-trichlorfenolis) heksachlorofenas |
| Hungarian magyar | 2,2'-metilénbisz-(3,4,6-triklórfenol) hexaklorofén |
| Maltese Malti | 2,2'-metilenbis-(3,4,6-triklorofenol) eżaklorofen |
| Dutch Nederlands | 2,2'-methyleen-bis-(3,4,6-trichloorfenol) hexachlorofeen |
| Polish polski | 2,2'-metylenobis(3,4,6-trichlorofenol) heksachlorofen |
| Portuguese português | 2,2'-metilenobis-(3,4,6-triclorofenol) hexaclorofeno |
| Romanian română | 2,2'-metilen-bis(3,4,6-triclorofenol) hexaclorofen |
| Slovak slovenčina | 3,3’,4,4’,6,6’-hexachlór-2,2'-metyléndifenol hexachlorofén |
| Slovenian slovenščina | 2,2'-metilenbis-(3,4,6-triklorofenol) heksaklorofen |
| Finnish suomi | 2,2'-metyleenibis-(3,4,6-trikloorifenoli) heksaklorofeeni |
| Swedish svenska | 2,2'-metylenbis-(3,4,6-triklorfenol) hexaklorofen |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
2,2'-methylenebis-(3,4,6-trich… GHS label elements
Everything CLP Annex VI fixes for 2,2'-methylenebis-(3,4,6-t…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
2,2'-methylenebis-(3,4,6-trich…
- Toxic in contact with skin.
- Toxic if swallowed.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- Immediately call a POISON CENTER/doctor/…
- Rinse mouth.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 2,2'-methylenebis-(3,4,6-t… in the GHS label constructor →
07 · Health hazards
2,2'-methylenebis-(3,4,6-trich… health hazards and exposure limits
2,2'-methylenebis-(3,4,6-trich… hazard summary
Hexachlorophene was removed from the over-the-counter market in the 1970s after neurotoxic effects were reported. Studies showed that between 0.3% and 6% of photo patch tested patients were allergic to this substance. [Marks, p. 232-3] Asthma reported in hospital employee; [Malo] In high-dose animal studies, hexachlorophene causes testicular damage and birth defects. [Frazier, p. 271-2] Acute exposure may cause CNS effects; A skin sensitizer; May cause asthma; [ICSC]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
2,2'-methylenebis-(3,4,6-trich… carcinogenicity classification
Studied by the US National Toxicology Program: TR-040: Bioassay of Hexachlorophene for Possible Carcinogenicity (CASRN 70-30-4) (1978 )
Classification of carcinogenicity: 1) evidence in humans: no data; 2) evidence in animals: inadequate. Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. /From table/
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
2,2'-methylenebis-(3,4,6-trich… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
2,2'-methylenebis-(3,4,6-trich… boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 166.5 °C (331.7 °F) | HMDB | |
| 479 °C (894.2 °F) | DrugBank |
2,2'-methylenebis-(3,4,6-trich… melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 165.5 °C (329.9 °F) | HSDB | |
| 164.17 °C (327.5 °F) | range, midpoint shown | CAMEO | |
| 164.5 °C (328.1 °F) | range, midpoint shown | ICSC |
2,2'-methylenebis-(3,4,6-trich… solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in chloroform, polyethylene glycols, propylene glycol, olive oil, cottonseed oil, dilute aqueous alkaline solutions. | HSDB | |
| Soluble at 1 in 3.5 parts of alcohol, 1 in less than 1 part of acetone, & 1 in less than 1 part of ether | HSDB | ||
| SOL IN DILUTE SOLUTIONS OF FIXED ALKALI HYDROXIDES | HSDB |
2,2'-methylenebis-(3,4,6-trich… flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 46.11 °C (115 °F) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
2,2'-methylenebis-(3,4,6-trich… storage and handling
2,2'-methylenebis-(3,4,6-trich… safe storage
Separated from food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
2,2'-methylenebis-(3,4,6-trich… storage conditions
Store at room temperature up to 25 °C (77 °F).
Source: Hazardous Substances Data Bank (HSDB)
2,2'-methylenebis-(3,4,6-trich… incompatible materials
Oxidizers.
Source: Hazardous Substances Data Bank (HSDB)
2,2'-methylenebis-(3,4,6-trich… reactivity
HEXACHLOROPHENE is incompatible with strong oxidizers. It forms salts with alkalis and alkaline earths. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 2,2'-methylenebis-(3,4,6… in the storage compatibility matrix →
10 · Transport
2,2'-methylenebis-(3,4,6-trich… UN number and transport classification
Transport classification is a separate system from the GHS classification above. It decides how a package is marked and how a load may be carried; it does not follow from the workplace label, and the workplace label does not follow from it. The entries below are linked by CAS number, never by name.
2,2'-methylenebis-(3,4,6-trich… under UN 2875 — shipping name, class and packing group
Europe · ADR 2025, Table A
| Proper shipping name (3.1.2) | Class | Classification code | PG | Labels (column 5) |
|---|---|---|---|---|
| HEXACHLOROPHENE | 6.1 | T2 | III | |
Source: ADR 2025, Table A of Chapter 3.2 · ECE/TRANS/352 Vol. I (UNECE). Class 6.1 is “Toxic substances” (ADR 2.1.1.1).
United States · 49 CFR 172.101 Hazardous Materials Table
| Proper shipping name (column 2) | Class or division | PG | Labels (column 6) |
|---|---|---|---|
| Hexachlorophene | 6.1 | III | |
Source: 49 CFR 172.101 Hazardous Materials Table · eCFR, revision 2026-08-03. Class 6.1 is “Poisonous materials” (49 CFR 173.2).
11 · Questions
2,2'-methylenebis-(3,4,6-trich… — frequently asked questions
What is the CAS number of 2,2'-methylenebis-(3,4,6-trich…?
The CAS number of 2,2'-methylenebis-(3,4,6-trich… is 70-30-4. Its EC number is 200-733-8.
What is the chemical formula of 2,2'-methylenebis-(3,4,6-trich…?
The molecular formula of 2,2'-methylenebis-(3,4,6-trich… is C13H6Cl6O2 and its molecular weight is 406.9 g/mol.
What does a 2,2'-methylenebis-(3,4,6-trich… label have to show?
Under CLP Annex VI the label for 2,2'-methylenebis-(3,4,6-trich… carries the pictograms Skull and crossbones and Environment and the signal word is Danger.
Is 2,2'-methylenebis-(3,4,6-trich… flammable?
CLP Annex VI assigns 2,2'-methylenebis-(3,4,6-trich… no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 46.11 °C (115 °F) (HSDB).
Is 2,2'-methylenebis-(3,4,6-trich… a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for 2,2'-methylenebis-(3,4,6-trich…. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health. IARC places it in Group 3: not classifiable as to its carcinogenicity to humans.
What is the boiling point of 2,2'-methylenebis-(3,4,6-trich…?
The boiling point reported for 2,2'-methylenebis-(3,4,6-trich… is 166.5 °C (331.7 °F) (HMDB).
What is the melting point of 2,2'-methylenebis-(3,4,6-trich…?
The melting point reported for 2,2'-methylenebis-(3,4,6-trich… is 165.5 °C (329.9 °F) (HSDB).
How should 2,2'-methylenebis-(3,4,6-trich… be stored?
Store at room temperature up to 25 °C (77 °F). (Hazardous Substances Data Bank (HSDB))
Nearby
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