Substance profile
2,4,6-Trichlorophenol
2,4,6-Trichlorophenol is crystals from ligroin with a strong phenolic odor.
01 · Identification
What 2,4,6-Trichlorophenol is
2,4,6-Trichlorophenol is crystals from ligroin with a strong phenolic odor. Its molecular formula is C6H3Cl3O and its molecular weight is 197.4 g/mol. It boils at 249 °C, melts at 69.5 °C.
Under the GHS it carries the signal word Warning. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
2,4,6-Trichlorophenol identifiers and molecular data
2,4,6-Trichlorophenol CAS number and EC number
2,4,6-Trichlorophenol molecular formula and molecular weight
03 · GHS classification
2,4,6-Trichlorophenol hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
2,4,6-Trichlorophenol pictograms and signal word
2,4,6-Trichlorophenol hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 2 | H351 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
2,4,6-Trichlorophenol hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H351 | Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H302 | Harmful if swallowed. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 2,4,6-Trichlorophenol. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 2,4,6-Trichlorophenol
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 2,4,6-Trichlorophenol issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
2,4,6-Trichlorophenol precautionary statements
CLP Annex VI assigns 18 precautionary statements to 2,4,6-Trichlorophenol. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
2,4,6-Trichlorophenol name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 2,4,6-трихлорофенол |
| Spanish español | 2,4,6-Triclorofenol |
| Czech čeština | 2,4,6-trichlorofenol |
| Danish dansk | 2,4,6-trichlorphenol |
| German Deutsch | 2,4,6-Trichlorphenol |
| Estonian eesti | 2,4,6-triklorofenool |
| Greek ελληνικά | 2,4,6-τριχλωροφαινόλη |
| English English | 2,4,6-trichlorophenol |
| French français | 2,4,6-trichlorophénol |
| Croatian hrvatski | 2,4,6-triklorfenol |
| Italian italiano | 2,4,6-triclorofenolo |
| Latvian latviešu | 2,4,6-trihlorfenols |
| Lithuanian lietuvių | 2,4,6-trichlorfenolis |
| Hungarian magyar | 2,4,6-triklórfenol |
| Maltese Malti | 2,4,6-triklorofenol |
| Dutch Nederlands | 2,4,6-trichloorfenol |
| Polish polski | 2,4,6-trichlorofenol |
| Portuguese português | 2,4,6-triclorofenol |
| Romanian română | 2,4,6-triclorofenol |
| Slovak slovenčina | 2,4,6-trichlórfenol |
| Slovenian slovenščina | 2,4,6-triklorofenol |
| Finnish suomi | 2,4,6-trikloorifenoli |
| Swedish svenska | 2,4,6-triklorfenol |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
2,4,6-Trichlorophenol GHS label elements
Everything CLP Annex VI fixes for 2,4,6-Trichlorophenol, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
2,4,6-Trichlorophenol
- Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful if swallowed.
- Causes skin irritation.
- Causes serious eye irritation.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF IN EYES:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 2,4,6-Trichlorophenol in the GHS label constructor →
07 · Health hazards
2,4,6-Trichlorophenol health hazards and exposure limits
2,4,6-Trichlorophenol hazard summary
2,4,6-Trichlorophenol is no longer used in the United States and only very low levels have been detected in ambient air. Limited information is available on the acute (short-term) and chronic (long-term) effects of 2,4,6-trichlorophenol in humans. The only available human study reported respiratory effects, such as cough, chronic bronchitis, chest wheezing, altered pulmonary function, and pulmonary lesions from chronic exposure to 2,4,6-trichlorophenol via inhalation. There are no studies available on the reproductive, developmental, or carcinogenic effects of 2,4,6-trichlorophenol in humans. 2,4,6- Trichlorophenol has been shown to be carcinogenic in animals, producing lymphomas, leukemia, and liver cancer via oral exposure. EPA has classified 2,4,6-trichlorophenol as a Group B2, probable human carcinogen.
Source: EPA Hazardous Air Pollutants
2,4,6-Trichlorophenol carcinogenicity classification
Studied by the US National Toxicology Program: TR-155: Bioassay of 2,4,6-Trichlorophenol for Possible Carcinogenicity (CASRN 88-06-2) (1979 )
CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Based on no human data and sufficient evidence in animals; namely, increased incidence of lymphomas or leukemia in male rats and hepatocellular adenomas or carcinomas in male and female mice. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: Sufficient.
Source: Hazardous Substances Data Bank (HSDB)
Evaluation: There is limited evidence in humans for the carcinogenicity of combined exposures to polychlorophenols or to their sodium salts. There is limited evidence in experimental animals for the carcinogenicity of 2,4,6-trichlorophenol. Overall evaluation: Combined exposures to polychlorophenols or to their sodium salts are possibly carcinogenic to humans (Group 2B). /Polychlorophenols/
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
2,4,6-Trichlorophenol properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
2,4,6-Trichlorophenol boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 249 °C (480.2 °F) | HSDB | |
| 246.11 °C (475 °F) | at 760 mmHg | CAMEO | |
| 246 °C (474.8 °F) | ICSC |
2,4,6-Trichlorophenol melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 69.5 °C (157.1 °F) | HSDB | |
| 69 °C (156.2 °F) | ICSC |
2,4,6-Trichlorophenol density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.4901 g/cm³ | HSDB | |
| 1.675 g/cm³ | at 25 °C | CAMEO | |
| 1.7 g/cm³ | at 25 °C | ICSC |
2,4,6-Trichlorophenol solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in ethanol, ethyl ether, acetic acid | HSDB | |
| In water, 500 mg/L at 25 °C | at 25 °C | HSDB |
2,4,6-Trichlorophenol vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.008 mmHg | at 25 °C | HSDB |
| 0.75 mmHg | at 71.8 °C | DOE PAC | |
| 1 mmHg | at 76.5 °C | CAMEO |
2,4,6-Trichlorophenol flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 99 °C (210.2 °F) | ICSC |
2,4,6-Trichlorophenol odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | 100 ug/L at 30 °C; 1,222 ug/L at 25 °C | at 30 °C, Purity not specified | HSDB |
| Odor Threshold Low: 200.0 [ppm] | Haz-Map | ||
| Odor threshold (recognition) from CHEMINFO | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
2,4,6-Trichlorophenol fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
2,4,6-Trichlorophenol fire potential
Non-combustible /Trichlorophenol/
Source: Hazardous Substances Data Bank (HSDB)
Solubility
525 g/100 g acetone; 113 g/100 g benzene; 37 g/100 g carbon tetrachloride; 335 g/100 g diacetone alcohol; 400 g/100 g denatured alcohol formula; 525 g/100 g methanol; 163 g/100 g pine oil; 16 g/100 g Stoddard solvent; 100 g/100 g toluene; 37 g/100 g turpentine
Source: HSDB
10 · Handling and storage
2,4,6-Trichlorophenol storage and handling
2,4,6-Trichlorophenol safe storage
Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Well closed. Store in an area without drain or sewer access.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
2,4,6-Trichlorophenol storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
2,4,6-Trichlorophenol incompatible materials
Incompatible materials: Strong oxidizing agents.
Source: Hazardous Substances Data Bank (HSDB)
2,4,6-Trichlorophenol reactivity
2,4,6-TRICHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents. It can be converted to the sodium salt by reaction with sodium carbonate. Forms ethers, esters and salts by reaction with metals and amines. Undergoes substitution reactions such as nitration, alkylation, acetylation and halogenation. Can be hydrolyzed by reaction with bases at elevated temperatures and pressures. Reacts with alkalis at high temperatures (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 2,4,6-Trichlorophenol in the storage compatibility matrix →
11 · Questions
2,4,6-Trichlorophenol — frequently asked questions
What is the CAS number of 2,4,6-Trichlorophenol?
The CAS number of 2,4,6-Trichlorophenol is 88-06-2. Its EC number is 201-795-9.
What is the chemical formula of 2,4,6-Trichlorophenol?
The molecular formula of 2,4,6-Trichlorophenol is C6H3Cl3O and its molecular weight is 197.4 g/mol.
What does a 2,4,6-Trichlorophenol label have to show?
Under CLP Annex VI the label for 2,4,6-Trichlorophenol carries the pictograms Health hazard, Exclamation mark and Environment and the signal word is Warning.
Is 2,4,6-Trichlorophenol flammable?
CLP Annex VI assigns 2,4,6-Trichlorophenol no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 99 °C (210.2 °F) (ICSC).
Is 2,4,6-Trichlorophenol a carcinogen?
CLP Annex VI assigns 2,4,6-Trichlorophenol H351 — suspected of causing cancer. That is category 2: the evidence points that way but is not conclusive. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of 2,4,6-Trichlorophenol?
The boiling point reported for 2,4,6-Trichlorophenol is 249 °C (480.2 °F) (HSDB).
What is the melting point of 2,4,6-Trichlorophenol?
The melting point reported for 2,4,6-Trichlorophenol is 69.5 °C (157.1 °F) (HSDB).
How should 2,4,6-Trichlorophenol be stored?
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ (Hazardous Substances Data Bank (HSDB))
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