Substance profile
4,4-Diaminodiphenylmethane
4,4-Diaminodiphenylmethane is crystals from water or benzene with a faint, amine-like odor.
01 · Identification
What 4,4-Diaminodiphenylmethane is
4,4-Diaminodiphenylmethane is crystals from water or benzene with a faint, amine-like odor. Its molecular formula is C13H14N2 and its molecular weight is 198.26 g/mol. It boils at 398 °C, melts at 92.5 °C.
Under the GHS it carries the signal word Danger. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
4,4-Diaminodiphenylmethane identifiers and molecular data
4,4-Diaminodiphenylmethane CAS number and EC number
4,4-Diaminodiphenylmethane molecular formula and molecular weight
Other names for 4,4-Diaminodiphenylmethane
- 4,4'-diaminodiphenylmethane
- 4,4'-methylenedianiline
03 · GHS classification
4,4-Diaminodiphenylmethane hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
4,4-Diaminodiphenylmethane pictograms and signal word
4,4-Diaminodiphenylmethane hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Germ cell mutagenicity GHS chapter 3.5 | Category 2 | H341 | GHS08 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Specific target organ toxicity - single exposure GHS chapter 3.8 | Category 1 | H370 | GHS08 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 2 | H373 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 2 | H411 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
4,4-Diaminodiphenylmethane hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H341 | Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H370 | Causes damage to organs <or state all organs affected, if known> <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H373 | May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H317 | May cause an allergic skin reaction. |
| H411 | Toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 4,4-Diaminodiphenylmethane. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 4,4-Diaminodiphenylmethane
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 4,4-Diaminodiphenylmet… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
4,4-Diaminodiphenylmethane precautionary statements
CLP Annex VI assigns 14 precautionary statements to 4,4-Diaminodiphenylmethane. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
4,4-Diaminodiphenylmethane name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 4,4′-диаминодифенилметан 4,4′-метилендианилин |
| Spanish español | 4,4'-Diaminodifenilmetano 4,4'-metilendianilina |
| Czech čeština | 4,4'-diaminodifenylmethan 4,4'-methylendianilin |
| Danish dansk | 4,4'-diaminodiphenylmethan 4,4'-methylendianilin |
| German Deutsch | 4,4'-Diaminodiphenylmethan 4,4'-Methylendianilin |
| Estonian eesti | 4,4'-diaminodifenüülmetaan 4,4'-metüleendianiliin |
| Greek ελληνικά | 4,4′-διαμινοδιφαινυλομεθάνιο 4,4′-μεθυλενοδιανιλίνη |
| English English | 4,4'-diaminodiphenylmethane 4,4'-methylenedianiline |
| French français | 4,4'-diaminodiphénylméthane 4,4'-méthylènedianiline |
| Croatian hrvatski | 4,4'-diaminodifenilmetan 4,4'-metilendianilin |
| Italian italiano | 4,4'-diaminodifenilmetano 4,4'-metilendianilina |
| Latvian latviešu | 4,4'-diaminodifenilmetāns 4,4'-metilēndianilīns |
| Lithuanian lietuvių | 4,4′-diaminodifenilmetanas 4,4'-metilendianilinas |
| Hungarian magyar | 4,4'-diaminodifenilmetán 4,4'-metiléndianilin |
| Maltese Malti | 4,4'-diamminodifenilmetan 4,4'-metilindianilina |
| Dutch Nederlands | 4,4'-diaminodifenylmethaan 4,4'-methyleendianiline |
| Polish polski | 4,4'-diaminodifenylometan 4,4'-metylenodianilina |
| Portuguese português | 4,4'-diaminodifenilmetano 4,4'-metilenodianilina |
| Romanian română | 4,4'-diaminodifenilmetan 4,4'-metilendianilină |
| Slovak slovenčina | 4,4'-diaminodifenylmetán 4,4'-metyléndianilín |
| Slovenian slovenščina | 4,4'-diaminodifenilmetan 4,4'-metilendianilin |
| Finnish suomi | 4,4'-diaminodifenyylimetaani 4,4'-metyleenidianiliini |
| Swedish svenska | 4,4'-diaminodifenylmetan 4,4'-metylendianilin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
4,4-Diaminodiphenylmethane GHS label elements
Everything CLP Annex VI fixes for 4,4-Diaminodiphenylmethane, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
4,4-Diaminodiphenylmethane
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Causes damage to organs <or state all organs affected, if known> <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May cause an allergic skin reaction.
- Toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF exposed or concerned:
- Call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Get medical advice/attention if you feel unwell.
- If skin irritation or rash occurs:
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 4,4-Diaminodiphenylmethane in the GHS label constructor →
07 · Health hazards
4,4-Diaminodiphenylmethane health hazards and exposure limits
4,4-Diaminodiphenylmethane hazard summary
4,4'-Methylenedianiline is an industrial chemical that is not known to occur naturally. It is also commonly known as diaminodiphenylmethane or MDA. It occurs as a colorless to pale yellow solid and has a faint odor. 4,4'-Methylenedianiline is used mainly for making polyurethane foams, which have a variety of uses, such as insulating materials in mailing containers. It is also used for making coating materials, glues, Spandex® fiber, dyes, and rubber.
Source: Agency for Toxic Substances and Disease Registry (ATSDR)
4,4-Diaminodiphenylmethane carcinogenicity classification
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
4,4'-Methylenedianiline: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
4,4-Diaminodiphenylmethane occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 0.01 [ppm], STEL(OSHA) = 0.1 ppm | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | 10 ppb [5 ppb Action Level] | Occupational Safety and Health Administration (OSHA) |
| PEL | 100 ppb | Occupational Safety and Health Administration (OSHA) |
| REL | Ca See Appendix A | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | A potential occupational carcinogen. (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | NIOSH considers 4,4'-methylenedianiline be a potential occupational carcinogen. | Hazardous Substances Data Bank (HSDB) |
| IDLH | Ca [N.D.] | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
4,4-Diaminodiphenylmethane properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
4,4-Diaminodiphenylmethane boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 398 °C (748.4 °F) | HSDB | |
| 397.78 °C (748 °F) | NIOSH |
4,4-Diaminodiphenylmethane melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 92.5 °C (198.5 °F) | HSDB | |
| 92.22 °C (198 °F) | NIOSH |
4,4-Diaminodiphenylmethane density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 0.5 g/cm³ | ICSC | |
| 1.15 g/cm³ | OSHA | ||
| 1.15 g/cm³ | at 25 °C | CAMEO |
4,4-Diaminodiphenylmethane solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Slightly sol in cold water. Very sol in alcohol, benzene, ether | HSDB | |
| Solubility (g/100mL solvent at 25 °C): 273.0 in acetone; 9.0 in benzene; 0.7 in carbon tetrachloride; 9.5 in ethyl ether; 143.0 in methanol; 0.1 in water | at 25 °C | HSDB | |
| In water, 1.00X10+3 mg/L at 25 °C | at 25 °C | HSDB |
4,4-Diaminodiphenylmethane vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 2.03e-7 mmHg | at 25 °C | HSDB |
| 2e-7 mmHg | at 25 °C | NIOSH | |
| 1e-7 mmHg | at 25 °C, calculated | CAMEO |
4,4-Diaminodiphenylmethane flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 220 °C (428 °F) | closed cup | HSDB |
| 190 °C (374 °F) | NIOSH | ||
| 221.11 °C (430 °F) | CAMEO |
4,4-Diaminodiphenylmethane lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Combustible Solid | NIOSH |
4,4-Diaminodiphenylmethane vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 6.8 (air = 1) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
4,4-Diaminodiphenylmethane fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
4,4-Diaminodiphenylmethane fire potential
Combustable when exposed to hear or flame.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
4,4-Diaminodiphenylmethane storage and handling
4,4-Diaminodiphenylmethane safe storage
Separated from strong oxidants and food and feedstuffs. Well closed. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
4,4-Diaminodiphenylmethane storage conditions
MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED...
Source: Hazardous Substances Data Bank (HSDB)
4,4-Diaminodiphenylmethane incompatible materials
Strong oxidizers.
Source: Hazardous Substances Data Bank (HSDB)
4,4-Diaminodiphenylmethane reactivity
4,4'-DIAMINODIPHENYLMETHANE polymerizes if heated above 257 °F. Incompatible with strong oxidizing agents. It is also incompatible with acids. Catalyzes isocyanate-alcohol and epoxide reactions. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4,4-Diaminodiphenylmethan… in the storage compatibility matrix →
11 · Questions
4,4-Diaminodiphenylmethane — frequently asked questions
What is the CAS number of 4,4-Diaminodiphenylmethane?
The CAS number of 4,4-Diaminodiphenylmethane is 101-77-9. Its EC number is 202-974-4.
What is the chemical formula of 4,4-Diaminodiphenylmethane?
The molecular formula of 4,4-Diaminodiphenylmethane is C13H14N2 and its molecular weight is 198.26 g/mol.
What does a 4,4-Diaminodiphenylmethane label have to show?
Under CLP Annex VI the label for 4,4-Diaminodiphenylmethane carries the pictograms Health hazard, Exclamation mark and Environment and the signal word is Danger.
Is 4,4-Diaminodiphenylmethane flammable?
CLP Annex VI assigns 4,4-Diaminodiphenylmethane no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 220 °C (428 °F), closed cup (HSDB).
Is 4,4-Diaminodiphenylmethane a carcinogen?
Yes. CLP Annex VI classifies 4,4-Diaminodiphenylmethane as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the exposure limit for 4,4-Diaminodiphenylmethane?
The US occupational exposure limit reported for 4,4-Diaminodiphenylmethane is 0.01 [ppm], STEL(OSHA) = 0.1 ppm (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of 4,4-Diaminodiphenylmethane?
The boiling point reported for 4,4-Diaminodiphenylmethane is 398 °C (748.4 °F) (HSDB).
What is the melting point of 4,4-Diaminodiphenylmethane?
The melting point reported for 4,4-Diaminodiphenylmethane is 92.5 °C (198.5 °F) (HSDB).
How should 4,4-Diaminodiphenylmethane be stored?
MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED... (Hazardous Substances Data Bank (HSDB))
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