Substance profile
4,4'-oxydianiline and its salts
4,4'-oxydianiline and its salts is colorless crystals.
01 · Identification
What 4,4'-oxydianiline and its… is
4,4'-oxydianiline and its salts is colorless crystals. Its molecular formula is C12H12N2O and its molecular weight is 200.24 g/mol. It boils at 300 °C, melts at 187 °C.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
4,4'-oxydianiline and its… identifiers and molecular data
4,4'-oxydianiline and its… CAS number and EC number
4,4'-oxydianiline and its… molecular formula and molecular weight
Other names for 4,4'-oxydianiline and its…
- p-aminophenyl ether
03 · GHS classification
4,4'-oxydianiline and its… hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
4,4'-oxydianiline and its… pictograms and signal word
4,4'-oxydianiline and its… hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 3 | H331 | GHS06 |
| Germ cell mutagenicity GHS chapter 3.5 | Category 1A or 1B | H340 | GHS08 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 2 | H411 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
4,4'-oxydianiline and its… hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H340 | May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H361f | Suspected of damaging fertility. |
| H331 | Toxic if inhaled. |
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
| H411 | Toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 4,4'-oxydianiline and its…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 4,4'-oxydianiline and its…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 4,4'-oxydianiline and… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
4,4'-oxydianiline and its… precautionary statements
CLP Annex VI assigns 16 precautionary statements to 4,4'-oxydianiline and its…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
4,4'-oxydianiline and its… name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 4,4′-оксидианилин и негови соли p -аминофенилов етер |
| Spanish español | 4,4'-Oxidianilina y sus sales éter de p -aminofenilo |
| Czech čeština | 4,4'-oxydianilin a jeho soli bis(4-aminofenyl)ether |
| Danish dansk | 4,4'-oxydianilin, salte heraf p -aminophenylether |
| German Deutsch | 4,4'-Oxydianilin und seine Salze p -Aminophenylether |
| Estonian eesti | 4,4'-oksüdianiliin ja selle soolad p -aminofenüüleeter |
| Greek ελληνικά | 4,4′-οξυδιανιλίνη και τα άλατά της p -αμινοφαινυλαιθέρας |
| English English | 4,4'-oxydianiline and its salts p -aminophenyl ether |
| French français | 4,4'-oxydianiline et ses sels oxyde de p -aminophényle |
| Croatian hrvatski | 4,4'-oksidianilin i njegove soli p -aminofenil eter |
| Italian italiano | 44,4'-ossidianilina e suoi sali p- amminofenil etere |
| Latvian latviešu | 4,4'-oksidianilīns un tā sāļi p -aminofenilēteris |
| Lithuanian lietuvių | 4,4'-4,4'-oksidianilinas ir jo druskos p -aminofenileteris |
| Hungarian magyar | 4,4’-oxidianilin és sói p -aminofenil-éter |
| Maltese Malti | 4,4'-ossidianilina u l-imluħa tagħha eter ta’ p -amminofenil |
| Dutch Nederlands | 4,4'-oxydianiline [1] en zijn zouten; p -aminofenylether This language edition of Annex VI files more than one substance under this single entry, so the cell is reproduced as printed: the [1] [2] markers say which name belongs to which member, and the members carry different CAS numbers. |
| Polish polski | 4,4'-oksydianilina i jej sole eter p -aminofenylowy |
| Portuguese português | 4,4'-oxidianilina e sais de 4,4'-oxidianilina éter p -aminofenílico |
| Romanian română | 4,4'-oxidianilină și sărurile sale p -aminofenil-eter |
| Slovak slovenčina | 4,4'-oxydianilín a jeho soli bis(4-aminofenyl)éter |
| Slovenian slovenščina | 4,4'-oksidianilin in njegove soli p -aminofenilni eter |
| Finnish suomi | 4,4’-oksidianiliini ja sen suolat p -aminofenyylieetteri |
| Swedish svenska | 4,4'-oxidianilin och dess salter p -aminofenyleter |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Where a cell is shown exactly as printed, the note beside it says why. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
4,4'-oxydianiline and its… GHS label elements
Everything CLP Annex VI fixes for 4,4'-oxydianiline and its…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
4,4'-oxydianiline and its…
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Suspected of damaging fertility.
- Toxic if inhaled.
- Toxic in contact with skin.
- Toxic if swallowed.
- Toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF exposed or concerned:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Rinse mouth.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 4,4'-oxydianiline and its… in the GHS label constructor →
07 · Health hazards
4,4'-oxydianiline and its… health hazards and exposure limits
4,4'-oxydianiline and its… hazard summary
Harmful by inhalation, ingestion, and skin absorption; May cause irritation; [CAMEO] An irritant; May induce methemoglobinemia; [MSDSonline]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
4,4'-oxydianiline and its… carcinogenicity classification
Under the conditions of this bioassay, 4,4'-oxydianiline was carcinogenic for male and female F344 rats, inducing hepatocellular carcinomas or neoplastic nodules and follicular-cell adenomas or carcinomas of the thyroid. 4,4'-Oxydianiline was also carcinogenic for male and female B6C3F1 mice, including adenomas in the harderian glands, hepatocellular adenomas or carcinomas in both sexes, and follicular-cell adenomas in the thyroid of females.
Source: US National Toxicology Program · TR-205: Bioassay of 4,4'-Oxydianiline for Possible Carcinogenicity (CASRN 101-80-4) (1980 )
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
4,4'-Oxydianiline: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
4,4'-oxydianiline and its… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
4,4'-oxydianiline and its… boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 300 °C (572 °F) | above this value | HSDB |
| Sublimes (NTP, 1992) | sublimes | CAMEO |
4,4'-oxydianiline and its… melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 187 °C (368.6 °F) | DOE PAC | |
| 186.67 °C (368 °F) | range, midpoint shown | CAMEO | |
| 189 °C (372.2 °F) | decomposes | HSDB |
4,4'-oxydianiline and its… solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Insoluble in water, benzene, carbon tetrachloride and ethanol; soluble in acetone | HSDB | |
| less than 0.1 mg/mL at 59 °F (NTP, 1992) | at 15 °C | CAMEO |
4,4'-oxydianiline and its… vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 3e-7 mmHg | at 25 °C | DOE PAC |
| 10 mmHg | at 240 °C | CAMEO | |
| 0.00000436 mmHg | Haz-Map |
4,4'-oxydianiline and its… flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 219 °C (426.2 °F) | closed cup | HSDB |
| 218.89 °C (426 °F) | CAMEO | ||
| 219 °C (426.2 °F) | Haz-Map |
4,4'-oxydianiline and its… autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 490 °C (914 °F) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
4,4'-oxydianiline and its… storage and handling
4,4'-oxydianiline and its… storage conditions
Stable under recommended storage conditions.
Source: Hazardous Substances Data Bank (HSDB)
4,4'-oxydianiline and its… reactivity
4,4'-DIAMINODIPHENYL ETHER oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. A mixture of liquid air and diethyl ether exploded spontaneously [MCA Case History 616(1960)].
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4,4'-oxydianiline and… in the storage compatibility matrix →
10 · Questions
4,4'-oxydianiline and its… — frequently asked questions
What is the CAS number of 4,4'-oxydianiline and its…?
The CAS number of 4,4'-oxydianiline and its… is 101-80-4. Its EC number is 202-977-0.
What is the chemical formula of 4,4'-oxydianiline and its…?
The molecular formula of 4,4'-oxydianiline and its… is C12H12N2O and its molecular weight is 200.24 g/mol.
What does a 4,4'-oxydianiline and its… label have to show?
Under CLP Annex VI the label for 4,4'-oxydianiline and its… carries the pictograms Skull and crossbones, Health hazard and Environment and the signal word is Danger.
Is 4,4'-oxydianiline and its… flammable?
CLP Annex VI assigns 4,4'-oxydianiline and its… no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 219 °C (426.2 °F), closed cup (HSDB).
Is 4,4'-oxydianiline and its… a carcinogen?
Yes. CLP Annex VI classifies 4,4'-oxydianiline and its… as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of 4,4'-oxydianiline and its…?
The boiling point reported for 4,4'-oxydianiline and its… is 300 °C (572 °F), above this value (HSDB).
What is the melting point of 4,4'-oxydianiline and its…?
The melting point reported for 4,4'-oxydianiline and its… is 187 °C (368.6 °F) (DOE PAC).
How should 4,4'-oxydianiline and its… be stored?
Stable under recommended storage conditions. (Hazardous Substances Data Bank (HSDB))
Nearby
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