Substance profile
4-Ethoxyaniline
4-Ethoxyaniline: p-phenetidine is a colorless to dark red liquid.
01 · Identification
What 4-Ethoxyaniline is
4-Ethoxyaniline: p-phenetidine is a colorless to dark red liquid. It boils at 250 °C, melts at 2.4 °C.
Under the GHS it carries the signal word Warning.
02 · Identifiers
4-Ethoxyaniline identifiers and molecular data
4-Ethoxyaniline CAS number and EC number
Other names for 4-Ethoxyaniline
- p-phenetidine
03 · GHS classification
4-Ethoxyaniline hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
4-Ethoxyaniline pictograms and signal word
4-Ethoxyaniline hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 4 | H312 | GHS07 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 4 | H332 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Germ cell mutagenicity GHS chapter 3.5 | Category 2 | H341 | GHS08 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
4-Ethoxyaniline hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H341 | Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H332 | Harmful if inhaled. |
| H312 | Harmful in contact with skin. |
| H302 | Harmful if swallowed. |
| H319 | Causes serious eye irritation. |
| H317 | May cause an allergic skin reaction. |
This page lists only the codes assigned to 4-Ethoxyaniline. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 4-Ethoxyaniline
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 4-Ethoxyaniline issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
4-Ethoxyaniline precautionary statements
CLP Annex VI assigns 20 precautionary statements to 4-Ethoxyaniline. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
4-Ethoxyaniline name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 4-етоксианилин p -фенетидин |
| Spanish español | 4-Etoxianilina p -fenetidina |
| Czech čeština | 4-ethoxyanilin p -fenetidin |
| Danish dansk | 4-ethoxyanilin p -phenetidin |
| German Deutsch | 4-Ethoxyanilin p -Phenetidin |
| Estonian eesti | 4-etoksüaniliin p -fenetidiin |
| Greek ελληνικά | 4-αιθοξυανιλίνη p -φαινετιδίνη |
| English English | 4-ethoxyaniline p -phenetidine |
| French français | 4-éthoxyaniline p -phénétidine |
| Croatian hrvatski | 4-etoksianilin p -fenetidin |
| Italian italiano | 4-etossianilina p -fenetidina |
| Latvian latviešu | 4-etoksianilīns p -fenetidīns |
| Lithuanian lietuvių | 4-etoksianilinas p -fenetidinas |
| Hungarian magyar | 4-etoxianilin p -fenetidin |
| Maltese Malti | 4-etossianilina p -fenetidina |
| Dutch Nederlands | 4-ethoxyaniline p -fenetidine |
| Polish polski | 4-etoksyanilina p -fenetydyna |
| Portuguese português | 4-etoxianilina p -fenetidina |
| Romanian română | 4-etoxianilină p -fenetidină |
| Slovak slovenčina | 4-etoxyanilín para -fenetidín |
| Slovenian slovenščina | 4-etoksianilin p -fenetidin |
| Finnish suomi | 4-etoksianiliini p -fenetidiini |
| Swedish svenska | 4-etoxianilin p -fenetidin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
4-Ethoxyaniline GHS label elements
Everything CLP Annex VI fixes for 4-Ethoxyaniline, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
4-Ethoxyaniline
- Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful if inhaled.
- Harmful in contact with skin.
- Harmful if swallowed.
- Causes serious eye irritation.
- May cause an allergic skin reaction.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Contaminated work clothing should not be allowed out of the workplace.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF IN EYES:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation or rash occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 4-Ethoxyaniline in the GHS label constructor →
07 · Health hazards
4-Ethoxyaniline health hazards and exposure limits
4-Ethoxyaniline hazard summary
An eye irritant; May induce methemoglobinemia; [ICSC] Causes methemoglobinemia in repeated-dose oral studies of rats; [RTECS] Toxic by ingestion, inhalation, and skin absorption; May cause contact irritation, cyanosis, hypothermia, headache, drowsiness, vomiting, nephritis, and alimentary tract irritation; [NTP] Case report of methemoglobinemia from occupational exposure; Sensitizing in 2 of 3 maximization tests of guinea pigs; Not a lung sensitizer in guinea pigs; Some evidence of skin sensitization in humans; [IUCLID] A strong eye irritant; May cause skin sensitization; Harmful by ingestion, inhalation, and skin absorption; Suspected mutagen; [Alfa Aesar MSDS] See m-Phenetidine. See p-Anisidine.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
4-Ethoxyaniline properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
4-Ethoxyaniline boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 250 °C (482 °F) | at 760 mmHg | CAMEO |
| 254 °C (489.2 °F) | range, midpoint shown | ICSC |
4-Ethoxyaniline melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 2.4 °C (36.3 °F) | ICSC | |
| 3.06 °C (37.5 °F) | range, midpoint shown | CAMEO |
4-Ethoxyaniline density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.1 g/cm³ | ICSC | |
| 1.0652 g/cm³ | at 16.11 °C | CAMEO | |
| Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.0 | at 20 °C | ICSC |
4-Ethoxyaniline solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | 5 to 10 mg/mL at 68 °F (NTP, 1992) | at 20 °C | CAMEO |
| Solubility in water, g/100ml at 20 °C: 2 (moderate) | at 20 °C | ICSC |
4-Ethoxyaniline vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 3.48 mmHg | at 25 °C | CAMEO |
| 0.075 mmHg | at 50 °C | ICSC | |
| 0.01 mmHg | Haz-Map |
4-Ethoxyaniline flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 115.56 °C (240 °F) | CAMEO | |
| 120 °C (248 °F) | ICSC |
4-Ethoxyaniline autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 425 °C (797 °F) | ICSC |
4-Ethoxyaniline vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4.73 (air = 1) | CAMEO | |
| 4.7 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
4-Ethoxyaniline storage and handling
4-Ethoxyaniline safe storage
Separated from strong oxidants and food and feedstuffs.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
4-Ethoxyaniline reactivity
P-PHENETIDINE reacts vigorously with powerful oxidizers.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4-Ethoxyaniline in the storage compatibility matrix →
10 · Questions
4-Ethoxyaniline — frequently asked questions
What is the CAS number of 4-Ethoxyaniline?
The CAS number of 4-Ethoxyaniline is 156-43-4. Its EC number is 205-855-5.
What does a 4-Ethoxyaniline label have to show?
Under CLP Annex VI the label for 4-Ethoxyaniline carries the pictograms Health hazard and Exclamation mark and the signal word is Warning.
Is 4-Ethoxyaniline flammable?
CLP Annex VI assigns 4-Ethoxyaniline no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 115.56 °C (240 °F) (CAMEO).
Is 4-Ethoxyaniline a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for 4-Ethoxyaniline. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of 4-Ethoxyaniline?
The boiling point reported for 4-Ethoxyaniline is 250 °C (482 °F), at 760 mmHg (CAMEO).
What is the melting point of 4-Ethoxyaniline?
The melting point reported for 4-Ethoxyaniline is 2.4 °C (36.3 °F) (ICSC).
Nearby
Substances next to 4-Ethoxyaniline
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