Substance profile
Dimethylacetamide
Dimethylacetamide is a liquid with an AMINE odor.
01 · Identification
What Dimethylacetamide is
Dimethylacetamide is a liquid with an AMINE odor. Its molecular formula is C4H9NO and its molecular weight is 87.12 g/mol. It boils at 165 °C, melts at -18.6 °C, is soluble in water.
Under the GHS it carries the signal word Danger. It is classed as flammable agents - 2nd degree.
02 · Identifiers
Dimethylacetamide identifiers and molecular data
Dimethylacetamide CAS number and EC number
Dimethylacetamide molecular formula and molecular weight
Other names for Dimethylacetamide
- N,N-dimethylacetamide
03 · GHS classification
Dimethylacetamide hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Dimethylacetamide pictograms and signal word
Dimethylacetamide hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - dermal GHS chapter 3.1 | Category 4 | H312 | GHS07 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 4 | H332 | GHS07 |
Dimethylacetamide hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H360D | May damage the unborn child. |
| H332 | Harmful if inhaled. |
| H312 | Harmful in contact with skin. |
This page lists only the codes assigned to Dimethylacetamide. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Dimethylacetamide
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Dimethylacetamide issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Dimethylacetamide precautionary statements
CLP Annex VI assigns 7 precautionary statements to Dimethylacetamide. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Dimethylacetamide name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | N , N -диметилацетамид |
| Spanish español | N,N -dimetilacetamida |
| Czech čeština | N , N -dimethylacetamid |
| Danish dansk | N,N-dimethylacetamid |
| German Deutsch | N,N-Dimethylacetamid |
| Estonian eesti | N , N -dimetüülatseetamiid |
| Greek ελληνικά | N , N -διμεθυλοακεταμίδιο |
| English English | N,N-dimethylacetamide |
| French français | N,N -diméthylacétamide |
| Croatian hrvatski | N,N-dimetilacetamid |
| Italian italiano | N,N-dimetilacetammide |
| Latvian latviešu | N,N -dimetilacetamīds |
| Lithuanian lietuvių | N,N-dimetilacetamidas |
| Hungarian magyar | N,N-dimetil-acetamid |
| Maltese Malti | N,N-dimetilaċetammid |
| Dutch Nederlands | N,N -dimethylacetamide |
| Polish polski | N , N -dimetyloacetamid |
| Portuguese português | N , N -dimetilacetamida |
| Romanian română | N,N-dimetilacetamidă |
| Slovak slovenčina | N,N-dimetylacetamid |
| Slovenian slovenščina | N,N-dimetilacetamid |
| Finnish suomi | N,N-dimetyyliasetamidi |
| Swedish svenska | N,N-dimetylacetamid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Dimethylacetamide GHS label elements
Everything CLP Annex VI fixes for Dimethylacetamide, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Dimethylacetamide
- May damage the unborn child.
- Harmful if inhaled.
- Harmful in contact with skin.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Use only outdoors or in a well-ventilated area.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF ON SKIN:
- IF INHALED:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Wash with plenty of water/…
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Dimethylacetamide in the GHS label constructor →
07 · Health hazards
Dimethylacetamide health hazards and exposure limits
Dimethylacetamide hazard summary
Toxic hepatitis has been reported in workers after inhalation and dermal exposure. DMAC is fetotoxic and teratogenic when administered at high doses to rabbits and rats. NOAEL = 25 ppm for hepatic and renal toxicity in rats and mice. Humans exposed to high doses may experience mental confusion. [ACGIH] A skin and eye irritant; Inhalation of high concentrations may cause liver and CNS effects; [ICSC] In a study of 440 new elastone fiber workers, 28 cases with elevated liver enzymes were detected in a 31 month period from 2002 to 2004. Using the BEI of 30 mg/g creatinine as a cutoff, the incidence of hepatic injury was about 7 times greater in the high exposure group. [Reference #1]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Dimethylacetamide carcinogenicity classification
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
Dimethylacetamide occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 10.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | 10 ppm (35 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| PEL | TWA 10 ppm (35 mg/m3) [skin] | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 10 ppm (35 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | TWA 10 ppm (35 mg/m3) [skin] | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | 300 ppm (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 300 ppm [From NPG: Dimethyl acetamide] (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 300.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Dimethylacetamide properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Dimethylacetamide boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 165 °C (329 °F) | NIOSH | |
| 166.11 °C (331 °F) | at 760 mmHg | CAMEO |
Dimethylacetamide melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -18.59 °C (-1.5 °F) | HSDB | |
| -20 °C (-4 °F) | NIOSH |
Dimethylacetamide density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 0.94 g/cm³ | NIOSH | |
| 0.943 g/cm³ | at 20 °C | CAMEO | |
| 0.9366 g/cm³ | at 25 °C | HSDB |
Dimethylacetamide solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | SOL IN BENZENE | HSDB | |
| Soluble in alcohol, acetone, ether | HSDB | ||
| Miscible with most org solvents | HSDB |
Dimethylacetamide vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 2 mmHg | NIOSH | |
| 2.4752 mmHg | at 20 °C | ICSC | |
| 2 mmHg | at 25 °C | HSDB |
Dimethylacetamide flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 70 °C (158 °F) | OPEN CUP | HSDB |
| 70 °C (158 °F) | NIOSH | ||
| 66.11 °C (151 °F) | CAMEO |
Dimethylacetamide autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 490 °C (914 °F) | HSDB |
Dimethylacetamide lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 1.8 % by volume | CAMEO |
Dimethylacetamide upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 13.8 % by volume | CAMEO | |
| 11.5 % by volume | ICSC | ||
| 11.5 % by volume | at 100 °C | HSDB |
Dimethylacetamide vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 3.01 (air = 1) | HSDB |
Dimethylacetamide odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | ODOR THRESHOLD FOR 50% RESPONSE IS 21.4 PPM; FOR 100% RESPONSE, 46.8 PPM. | HSDB | |
| Odor low: 163.8 mg/cu m; Odor high: 163.8 mg/cu m | HSDB | ||
| Odor Threshold Low: 21.0 [ppm] | Haz-Map |
Dimethylacetamide critical temperature and pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Critical temperature and pressure | 385 °C (725 °F) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Dimethylacetamide fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Dimethylacetamide fire potential
Combustible when exposed to heat or flame.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Dimethylacetamide storage and handling
Dimethylacetamide safe storage
Ventilation along the floor. Separated from strong oxidants.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Dimethylacetamide storage conditions
MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ... .
Source: Hazardous Substances Data Bank (HSDB)
Dimethylacetamide incompatible materials
Carbon tetrachloride, other halogenated compounds when in contact with iron, oxidizers.
Source: Hazardous Substances Data Bank (HSDB)
Dimethylacetamide reactivity
DIMETHYLACETAMIDE is an amide. Incompatible with oxidizing agents and halogenated compounds. Exothermic reactions occur with carbon tetrachloride and hexachlorocyclohexane. It can react violently in the presence of iron. (NTP, 1992) Special Hazards of Combustion Products: Emits carbon oxides, nitrogen oxides, and dimethylamine when heated to decomposition.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Dimethylacetamide in the storage compatibility matrix →
11 · Questions
Dimethylacetamide — frequently asked questions
What is the CAS number of Dimethylacetamide?
The CAS number of Dimethylacetamide is 127-19-5. Its EC number is 204-826-4.
What is the chemical formula of Dimethylacetamide?
The molecular formula of Dimethylacetamide is C4H9NO and its molecular weight is 87.12 g/mol.
What does a Dimethylacetamide label have to show?
Under CLP Annex VI the label for Dimethylacetamide carries the pictograms Health hazard and Exclamation mark and the signal word is Danger.
Is Dimethylacetamide flammable?
CLP Annex VI assigns Dimethylacetamide no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 70 °C (158 °F), OPEN CUP (HSDB).
Is Dimethylacetamide a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Dimethylacetamide. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the exposure limit for Dimethylacetamide?
The US occupational exposure limit reported for Dimethylacetamide is 10.0 [ppm] (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Dimethylacetamide?
The boiling point reported for Dimethylacetamide is 165 °C (329 °F) (NIOSH).
What is the melting point of Dimethylacetamide?
The melting point reported for Dimethylacetamide is -18.59 °C (-1.5 °F) (HSDB).
How should Dimethylacetamide be stored?
MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ... . (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Dimethylacetamide
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