Substance profile
N-Methylolacrylamide
N-methylolacrylamide appears as a colorless or yellow aqueous solution.
01 · Identification
What N-Methylolacrylamide is
N-methylolacrylamide appears as a colorless or yellow aqueous solution. It boils at 277 °C, melts at 75 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
N-Methylolacrylamide identifiers and molecular data
N-Methylolacrylamide CAS number and EC number
Other names for N-Methylolacrylamide
- N-(hydroxymethyl)acrylamide
- methylolacrylamide
- [NMA]
03 · GHS classification
N-Methylolacrylamide hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
N-Methylolacrylamide pictograms and signal word
N-Methylolacrylamide hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Germ cell mutagenicity GHS chapter 3.5 | Category 1A or 1B | H340 | GHS08 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 1 | H372 | GHS08 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
N-Methylolacrylamide hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H340 | May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H372 | Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
This page lists only the codes assigned to N-Methylolacrylamide. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for N-Methylolacrylamide
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of N-Methylolacrylamide issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
N-Methylolacrylamide precautionary statements
CLP Annex VI assigns 7 precautionary statements to N-Methylolacrylamide. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
N-Methylolacrylamide name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | N -(хидроксиметил)акрилмид метилолакриламид |
| Spanish español | N -(Hidroximetil)acrilamida metilolacrilamida |
| Czech čeština | N -(hydroxymethyl)akrylamid methylolakrylamid |
| Danish dansk | N -(hydroxymethyl)acrylamid methylolacrylamid |
| German Deutsch | N -(hydroxymethyl)acrylamid Methylolacrylamid |
| Estonian eesti | N -(hüdroksümetüül)akrüülamiid metüloolakrüülamiid |
| Greek ελληνικά | Ν -(υδροξυμεθυλ)ακρυλαμίδιο μεθυλολακρυλαμίδιο |
| English English | N -(hydroxymethyl)acrylamide methylolacrylamide |
| French français | N -(hydroxyméthyl)acrylamide méthylolacrylamide |
| Croatian hrvatski | N -(hidroksimetil)akrilamid metilolakrilamid |
| Italian italiano | N -(idrossimetil)acrilammide metilolacrilammide |
| Latvian latviešu | N -(hidroksimetil)akrilamīds metiloakrilamīds |
| Lithuanian lietuvių | N -(hidroksimetil)akrilamidas metilolakrilamidas |
| Hungarian magyar | N -(hidroximetil)akrilamid metilolakrilamid |
| Maltese Malti | N -(idrossimetil)akrilammid metilolakrilammid |
| Dutch Nederlands | N -(hydroxymethyl)acrylamide methylolacrylamide |
| Polish polski | N -(hydroksymetylo)akrylamid metylolakrylamid |
| Portuguese português | N -(hidroximetil)acrilamida metilolacrilamida |
| Romanian română | N -(hidroximetil)acrilamidă metilolacrilamidă |
| Slovak slovenčina | N -(hydroxymetyl)akrylamid metylolakrylamid |
| Slovenian slovenščina | N -(hidroksimetil)akrilamid metilolakrilamid |
| Finnish suomi | N -(hydroksimetyyli)akryyliamidi metyloliakryyliamidi |
| Swedish svenska | N -(hydroximetyl)akrylamid metylolakrylamid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
N-Methylolacrylamide GHS label elements
Everything CLP Annex VI fixes for N-Methylolacrylamide, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
N-Methylolacrylamide
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF exposed or concerned:
- Get medical advice/attention.
- Get medical advice/attention if you feel unwell.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open N-Methylolacrylamide in the GHS label constructor →
07 · Health hazards
N-Methylolacrylamide health hazards and exposure limits
N-Methylolacrylamide hazard summary
A skin, eye, mucous membrane, and respiratory tract irritant; Compounds in this class may cause peripheral neuropathy; Aqueous solution are readily absorbed through the skin; [CAMEO] The substance may have effects on the peripheral nervous system. [ICSC] An irritant; Readily absorbed through skin; Targets liver and lungs in high-dose animal studies; [MSDSonline] See Acrylamide.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
N-Methylolacrylamide carcinogenicity classification
Under the conditions of these 2-year studies, there was no evidence of carcinogenic activity of N-methylolacrylamide for male or female F344/N rats receiving doses of 6 or 12 mg/kg per day by aqueous gavage. There was clear evidence of carcinogenic activity of N-methylolacrylamide for male B6C3F1 mice, based on increased incidences of neoplasms of the Harderian gland, liver, and lung. There was clear evidence of carcinogenic activity of N-methylolacrylamide for female B6C3F1 mice, based on increased incidences of neoplasms of the Harderian gland, liver, lung, and ovary.
Source: US National Toxicology Program · TR-352: Toxicology and Carcinogenesis Studies of N-Methylolacrylamide (CASRN 924-42-5) in F344/N Rats and B6C3F1 Mice (1989 )
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
N-Methylolacrylamide properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
N-Methylolacrylamide boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 277 °C (530.6 °F) | ICSC |
N-Methylolacrylamide melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 75 °C (167 °F) | ICSC | |
| 74.44 °C (166 °F) | range, midpoint shown | CAMEO |
N-Methylolacrylamide density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.07 g/cm³ | at 25 °C | ICSC |
N-Methylolacrylamide solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | less than 1 mg/mL at 68.9 °F (NTP, 1992) | at 20.5 °C | CAMEO |
| Solubility in water, g/100ml at 20 °C: 188 (very soluble) | at 20 °C | ICSC |
N-Methylolacrylamide vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.000205 mmHg | Haz-Map | |
| Vapor pressure, Pa at 25 °C: 0.03 (negligible) | at 25 °C | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
N-Methylolacrylamide fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
N-Methylolacrylamide fire potential
AMONG 4 FIBER DRUMS OF THIS CHEMICAL /N-HYDROXYMETHYLACRYLAMIDE/, 2 OF WHICH HAD NEVER BEEN OPENED, EXCESSIVE HEAT, SMOKE, CRACKLING & SMALL FLAME WERE NOTED. VERY SMALL AMOUNTS OF CONTAMINANT ARE BELIEVED TO HAVE CATALYZED THIS POLYMERIZATION REACTION, BUT STORAGE IN EXCESSIVELY HEATED AREAS CAN ALSO START THE REACTION.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
N-Methylolacrylamide storage and handling
N-Methylolacrylamide safe storage
Cool. Separated from acids. Store only if stabilized. Keep in the dark. Store in an area without drain or sewer access.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
N-Methylolacrylamide incompatible materials
Excessive heat, smoke, flames, and cracking noise were emitted from stored fibre drums of the monomer, some unopened. Polymerization may have been initiated by minor contaminants (perhaps as vapors), and/or by excessively warm storage conditions.
Source: Hazardous Substances Data Bank (HSDB)
N-Methylolacrylamide reactivity
N-METHYLOLACRYLAMIDE may be sensitive to prolonged exposure to light. Polymerization and generation of heat and flames may occur on exposure to to heat or contaminants. Incompatible with strong oxidizers. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check N-Methylolacrylamide in the storage compatibility matrix →
11 · Questions
N-Methylolacrylamide — frequently asked questions
What is the CAS number of N-Methylolacrylamide?
The CAS number of N-Methylolacrylamide is 924-42-5. Its EC number is 213-103-2.
What does a N-Methylolacrylamide label have to show?
Under CLP Annex VI the label for N-Methylolacrylamide carries the pictogram Health hazard and the signal word is Danger.
Is N-Methylolacrylamide flammable?
CLP Annex VI assigns N-Methylolacrylamide no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is N-Methylolacrylamide a carcinogen?
Yes. CLP Annex VI classifies N-Methylolacrylamide as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of N-Methylolacrylamide?
The boiling point reported for N-Methylolacrylamide is 277 °C (530.6 °F) (ICSC).
What is the melting point of N-Methylolacrylamide?
The melting point reported for N-Methylolacrylamide is 75 °C (167 °F) (ICSC).
Nearby
Substances next to N-Methylolacrylamide
Keep going: substances starting with N, or search the whole database by name, CAS number, pictogram or signal word.