Substance profile
N,N-Dimethylaniline
N,N-Dimethylaniline is a pale-yellow, oily liquid with an amine-like odor.
01 · Identification
What N,N-Dimethylaniline is
N,N-Dimethylaniline is a pale-yellow, oily liquid with an amine-like odor. Its molecular formula is C8H11N and its molecular weight is 121.18 g/mol. It boils at 193 °C, melts at 2.1 °C.
Under the GHS it carries the signal word Danger. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
N,N-Dimethylaniline identifiers and molecular data
N,N-Dimethylaniline CAS number and EC number
N,N-Dimethylaniline molecular formula and molecular weight
03 · GHS classification
N,N-Dimethylaniline hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
N,N-Dimethylaniline pictograms and signal word
N,N-Dimethylaniline hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 3 | H331 | GHS06 |
| Carcinogenicity GHS chapter 3.6 | Category 2 | H351 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 2 | H411 | GHS09 |
N,N-Dimethylaniline hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H351 | Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H331 | Toxic if inhaled. |
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
| H411 | Toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to N,N-Dimethylaniline. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for N,N-Dimethylaniline
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of N,N-Dimethylaniline issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
N,N-Dimethylaniline precautionary statements
CLP Annex VI assigns 16 precautionary statements to N,N-Dimethylaniline. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
N,N-Dimethylaniline name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | N , N -диметиланилин |
| Spanish español | N , N -Dimetilanilina |
| Czech čeština | N , N -dimethylanilin |
| Danish dansk | N, N- dimethylanilin |
| German Deutsch | N , N -Dimethylanilin |
| Estonian eesti | N , N -dimetüülaniliin |
| Greek ελληνικά | N , N -διμεθυλανιλίνη |
| English English | N , N -dimethylaniline |
| French français | N , N -diméthylaniline |
| Croatian hrvatski | N , N -dimetilanilin |
| Italian italiano | N, N- dimetilanilina |
| Latvian latviešu | N , N -dimetilanilīns |
| Lithuanian lietuvių | N , N -dimetilanilinas |
| Hungarian magyar | N , N -dimetilanilin |
| Maltese Malti | N , N -dimetilanilina |
| Dutch Nederlands | N , N -dimethylaniline |
| Polish polski | N , N -dimetyloanilina |
| Portuguese português | N , N -dimetilanilina |
| Romanian română | N , N -dimetilanilină |
| Slovak slovenčina | N , N -dimetylanilín |
| Slovenian slovenščina | N , N -dimetilanilin |
| Finnish suomi | N , N -dimetyylianiliini |
| Swedish svenska | N , N -dimetylanilin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
N,N-Dimethylaniline GHS label elements
Everything CLP Annex VI fixes for N,N-Dimethylaniline, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
N,N-Dimethylaniline
- Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Toxic if inhaled.
- Toxic in contact with skin.
- Toxic if swallowed.
- Toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF exposed or concerned:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Rinse mouth.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open N,N-Dimethylaniline in the GHS label constructor →
07 · Health hazards
N,N-Dimethylaniline health hazards and exposure limits
N,N-Dimethylaniline hazard summary
N,N-Dimethylaniline is used as an intermediate in the manufacture of dyes and other substances. Acute (short-term) inhalation exposure to N,N-dimethylaniline has resulted in effects on the central nervous system (CNS) and circulatory system, with headache, cyanosis, and dizziness in humans. Effects on the blood have been reported in exposed workers. Chronic (long-term) inhalation exposure of animals resulted in effects on the CNS, blood, and liver. No information is available on the reproductive, developmental, or carcinogenic effects of N,N-dimethylaniline in humans. In a National Toxicology Program (NTP) study of rats and mice exposed via gavage, increased incidences of tumors of the spleen and forestomach were observed. EPA has not classified N,N-dimethylaniline for potential carcinogenicity.
Source: EPA Hazardous Air Pollutants
N,N-Dimethylaniline carcinogenicity classification
Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity of N,N-dimethylaniline for male F344/N rats, as indicated by the increased incidences of sarcomas or osteosarcomas (combined) of the spleen. There was no evidence of carcinogenic activity of N,N-dimethylanilinefor female F344/N rats given 3 or 30 mg/kg body weight by gavage for 2 years. There was no evidence of carcinogenic activity of N,N-dimethylaniline for male B6C3F1 mice given 15 or 30 mg/kg bodyweight by gavage for 2 years. There was equivocal evidence of carcinogenic activity of N,N-dimethylaniline for female B6C3F1 mice, as indicated by an increased incidence of squamous cell papillomas of the forestomach. Both rats and mice could have tolerated doses higher than those used in these studies.
Source: US National Toxicology Program · TR-360: Toxicology and Carcinogenesis Studies of N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1989 )
Evaluation: There is inadequate evidence in humans for the carcinogenicity of N,N-dimethylaniline. There is limited evidence in experimental animals for the carcinogenicity of N,N-dimethylaniline. Overall evaluation: N,N-dimethylaniline is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
N,N-Dimethylaniline occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 5.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | 5 ppm (25 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| PEL | TWA 5 ppm (25 mg/m3) [skin] See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 5 ppm (25 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | 10 ppm (50 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | TWA 5 ppm (25 mg/m3) ST 10 ppm (50 mg/m3) [skin] | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | 100 ppm (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 100.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| IDLH | 100 ppm | Hazardous Substances Data Bank (HSDB) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
N,N-Dimethylaniline properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
N,N-Dimethylaniline boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 193 °C (379.4 °F) | HSDB | |
| 192.22 °C (378 °F) | NIOSH | ||
| 193.89 °C (381 °F) | at 760 mmHg | CAMEO |
N,N-Dimethylaniline melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 2.1 °C (35.8 °F) | HSDB | |
| 2.22 °C (36 °F) | NIOSH | ||
| 2.44 °C (36.4 °F) | CAMEO |
N,N-Dimethylaniline density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 0.96 g/cm³ | NIOSH | |
| 0.9537 g/cm³ | at 20 °C | HSDB | |
| 0.9557 g/cm³ | at 20 °C | CAMEO |
N,N-Dimethylaniline solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Freely soluble in alcohol, chloroform, ether | HSDB | |
| Soluble in acetone, benzene, organic solvents | HSDB | ||
| In water, 1,454 mg/L at 25 °C | at 25 °C | HSDB |
N,N-Dimethylaniline vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 1 mmHg | NIOSH | |
| 0.5025 mmHg | at 20 °C | ICSC | |
| 0.7 mmHg | at 25 °C | HSDB |
N,N-Dimethylaniline flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 62.78 °C (145 °F) | HSDB | |
| 61.11 °C (142 °F) | NIOSH |
N,N-Dimethylaniline autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 371.11 °C (700 °F) | HSDB | |
| 371 °C (699.8 °F) | ICSC |
N,N-Dimethylaniline lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 1 % by volume | ICSC | |
| Explodes on contact with benzoyl peroxide or diisopropyl peroxydicarbonate. | HSDB | ||
| Class IIIA Combustible Liquid: Fl.P. at or above 140 °F and below 200 °F. | NIOSH |
N,N-Dimethylaniline upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 7 % by volume | ICSC |
N,N-Dimethylaniline vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4.17 (air = 1) | HSDB | |
| 4.2 (air = 1) | ICSC |
N,N-Dimethylaniline odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | Odor Threshold Low: 0.001 [ppm] | Haz-Map | |
| Odor Threshold High: 0.2 [ppm] | Haz-Map | ||
| Odor threshold from AIHA | Haz-Map |
N,N-Dimethylaniline critical temperature and pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Critical temperature and pressure | 414.55 °C (778.2 °F) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
N,N-Dimethylaniline fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
N,N-Dimethylaniline fire potential
Flammable liquid when exposed to heat, flame, or oxidizers.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
N,N-Dimethylaniline storage and handling
N,N-Dimethylaniline safe storage
Separated from strong oxidants and food and feedstuffs. Ventilation along the floor.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
N,N-Dimethylaniline storage conditions
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Source: Hazardous Substances Data Bank (HSDB)
N,N-Dimethylaniline incompatible materials
Explodes on contact with benzoyl peroxide or diisopropyl peroxydicarbonate.
Source: Hazardous Substances Data Bank (HSDB)
N,N-Dimethylaniline reactivity
Explosive decomposition occurred when finely divided benzoyl peroxide was allowed to react with N,N-DIMETHYLANILINE by breaking an ampoule containing 0.5 grams of dimethylaniline in an autoclave, NFPA 491M, 1991. This result may be expected with other peroxides and various oxidants.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check N,N-Dimethylaniline in the storage compatibility matrix →
11 · Questions
N,N-Dimethylaniline — frequently asked questions
What is the CAS number of N,N-Dimethylaniline?
The CAS number of N,N-Dimethylaniline is 121-69-7. Its EC number is 204-493-5.
What is the chemical formula of N,N-Dimethylaniline?
The molecular formula of N,N-Dimethylaniline is C8H11N and its molecular weight is 121.18 g/mol.
What does a N,N-Dimethylaniline label have to show?
Under CLP Annex VI the label for N,N-Dimethylaniline carries the pictograms Skull and crossbones, Health hazard and Environment and the signal word is Danger.
Is N,N-Dimethylaniline flammable?
CLP Annex VI assigns N,N-Dimethylaniline no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 62.78 °C (145 °F) (HSDB).
Is N,N-Dimethylaniline a carcinogen?
CLP Annex VI assigns N,N-Dimethylaniline H351 — suspected of causing cancer. That is category 2: the evidence points that way but is not conclusive. IARC places it in Group 3: not classifiable as to its carcinogenicity to humans.
What is the exposure limit for N,N-Dimethylaniline?
The US occupational exposure limit reported for N,N-Dimethylaniline is 5.0 [ppm] (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of N,N-Dimethylaniline?
The boiling point reported for N,N-Dimethylaniline is 193 °C (379.4 °F) (HSDB).
What is the melting point of N,N-Dimethylaniline?
The melting point reported for N,N-Dimethylaniline is 2.1 °C (35.8 °F) (HSDB).
How should N,N-Dimethylaniline be stored?
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. (Hazardous Substances Data Bank (HSDB))
Nearby
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