Substance profile
Pyrogallol
Pyrogallol is white, lustrous crystals or plates and is odorless.
01 · Identification
What Pyrogallol is
Pyrogallol is white, lustrous crystals or plates and is odorless. Its molecular formula is C6H6O3 and its molecular weight is 126.11 g/mol. It boils at 309 °C, melts at 133 °C, is very soluble in water.
Under the GHS it carries the signal word Warning.
02 · Identifiers
Pyrogallol identifiers and molecular data
Pyrogallol CAS number and EC number
Pyrogallol molecular formula and molecular weight
Other names for Pyrogallol
- 1,2,3-trihydroxybenzene
03 · GHS classification
Pyrogallol hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Pyrogallol pictograms and signal word
Pyrogallol hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 4 | H312 | GHS07 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 4 | H332 | GHS07 |
| Germ cell mutagenicity GHS chapter 3.5 | Category 2 | H341 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 3 | H412 | — |
Pyrogallol hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H341 | Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H332 | Harmful if inhaled. |
| H312 | Harmful in contact with skin. |
| H302 | Harmful if swallowed. |
| H412 | Harmful to aquatic life with long lasting effects. |
This page lists only the codes assigned to Pyrogallol. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Pyrogallol
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Pyrogallol issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Pyrogallol precautionary statements
CLP Annex VI assigns 15 precautionary statements to Pyrogallol. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Pyrogallol name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | пирогалол 1,2,3-трихидроксибензен |
| Spanish español | Pirogalol 1,2,3-trihidroxibenceno |
| Czech čeština | pyrogallol benzen-1,2,3-triol |
| Danish dansk | pyrogallol 1,2,3-trihydroxybenzen |
| German Deutsch | Pyrogallol 1,2,3-Trihydroxybenzol |
| Estonian eesti | pürogallool 1,2,3-trihüdroksübenseen |
| Greek ελληνικά | πυρογαλλόλη 1,2,3-τριυδροξυβενζόλιο |
| English English | pyrogallol 1,2,3-trihydroxybenzene |
| French français | pyrogallol 1,2,3-trihydroxybenzène |
| Croatian hrvatski | pirogalol 1,2,3-trihidroksibenzen |
| Italian italiano | pirogallolo 1,2,3-triidrossibenzene |
| Latvian latviešu | pirogallols 1,2,3-trihidroksibenzols |
| Lithuanian lietuvių | pirogalolis 1,2,3-trihidroksibenzenas |
| Hungarian magyar | pirogallol 1,2,3-trihidroxibenzol |
| Maltese Malti | pirogallol 1,2,3-triidrossibenżen |
| Dutch Nederlands | pyrogallol 1,2,3-trihydroxybenzeen |
| Polish polski | pirogalol 1,2,3-trihydroksybenzen |
| Portuguese português | pirogalhol 1,2,3-tri-hidroxibenzeno |
| Romanian română | pirogalol 1,2,3-trihidroxi benzen |
| Slovak slovenčina | pyrogalol benzén-1,2,3-triol |
| Slovenian slovenščina | pirogalol 1,2,3-trihidroksibenzen |
| Finnish suomi | pyrogalloli 1,2,3-trihydroksibentseeni |
| Swedish svenska | pyrogallol 1,2,3-trihydroxibensen |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Pyrogallol GHS label elements
Everything CLP Annex VI fixes for Pyrogallol, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Pyrogallol
- Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful if inhaled.
- Harmful in contact with skin.
- Harmful if swallowed.
- Harmful to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- Wash with plenty of water/…
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Pyrogallol in the GHS label constructor →
07 · Health hazards
Pyrogallol health hazards and exposure limits
Pyrogallol hazard summary
Reported human toxicity after ingestion includes methemoglobinemia, hemolysis of red blood cells, and damage to the liver and kidneys; [HSDB] An eye, respiratory tract, and mild skin irritant; May cause skin sensitization; [ICSC] Allergic contact dermatitis reported in hairdressers; [Kanerva, p. 1832] Toxic by ingestion with adverse effects including convulsions; [CAMEO]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Pyrogallol carcinogenicity classification
Under the conditions of these 2-year dermal studies, there was no evidence of carcinogenic activity of pyrogallol in male or female F344/N rats administered 5, 20, or 75 mg/kg. There was equivocal evidence of carcinogenic activity of pyrogallol in male B6C3F1/N mice based on increased incidences of squamous cell papilloma of the skin at the site of application. There was some evidence of carcinogenic activity of pyrogallol in female B6C3F1/N mice based on increased incidences of squamous cell carcinoma of the skin at the site of application. Dermal administration of pyrogallol caused increased incidences of nonneoplastic lesions of the skin at the site of application in male and female rats and mice, skin adjacent to the site of application in male and female mice, and mammary gland in female mice.
Source: US National Toxicology Program · TR-574: Toxicology and Carcinogenesis Studies of Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies) (2013 )
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Pyrogallol properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Pyrogallol boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 309 °C (588.2 °F) | HSDB | |
| 309 °C (588.2 °F) | at 760 mmHg | DOE PAC |
Pyrogallol melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 133 °C (271.4 °F) | HSDB | |
| 133.33 °C (272 °F) | range, midpoint shown | CAMEO | |
| 132.5 °C (270.5 °F) | range, midpoint shown | ICSC |
Pyrogallol density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.45 g/cm³ | ICSC | |
| 1.45 g/cm³ | at 20 °C | CAMEO | |
| 1.453 g/cm³ | at 4 °C | HSDB |
Pyrogallol solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Very soluble in ethanol, diethyl ether | HSDB | |
| 1 g dissolves in 1.7 mL water, 1.3 mL alcohol, 1.6 mL ether; slightly sol in benzene, chloroform, carbon disulfide | HSDB | ||
| Soluble in oxygenated solvents | HSDB |
Pyrogallol vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.000479 mmHg | at 25 °C | HSDB |
| 10 mmHg | at 167.72 °C | CAMEO | |
| 9.9758 mmHg | at 168 °C | ICSC |
Pyrogallol lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Finely dispersed particles form explosive mixtures in air. | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Pyrogallol fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Pyrogallol fire potential
Combustible
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Pyrogallol storage and handling
Pyrogallol safe storage
Separated from strong oxidants and strong bases.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Pyrogallol storage conditions
/Store/ separated from strong oxidants, strong bases.
Source: Hazardous Substances Data Bank (HSDB)
Pyrogallol incompatible materials
The solution in water is a weak acid. Reacts with oxidants and bases.
Source: Hazardous Substances Data Bank (HSDB)
Pyrogallol reactivity
PYROGALLIC ACID is a strong reducing agent. Reacts with alkalis, NH3, antipyrine, camphor, phenol, iron and lead salts, iodine, lime water, menthol and KMnO4. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Pyrogallol in the storage compatibility matrix →
11 · Questions
Pyrogallol — frequently asked questions
What is the CAS number of Pyrogallol?
The CAS number of Pyrogallol is 87-66-1. Its EC number is 201-762-9.
What is the chemical formula of Pyrogallol?
The molecular formula of Pyrogallol is C6H6O3 and its molecular weight is 126.11 g/mol.
What does a Pyrogallol label have to show?
Under CLP Annex VI the label for Pyrogallol carries the pictograms Health hazard and Exclamation mark and the signal word is Warning.
Is Pyrogallol flammable?
CLP Annex VI assigns Pyrogallol no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Pyrogallol a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Pyrogallol. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Pyrogallol?
The boiling point reported for Pyrogallol is 309 °C (588.2 °F) (HSDB).
What is the melting point of Pyrogallol?
The melting point reported for Pyrogallol is 133 °C (271.4 °F) (HSDB).
How should Pyrogallol be stored?
/Store/ separated from strong oxidants, strong bases. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Pyrogallol
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