Substance profile
Thiophanate-Methyl
Thiophanate-Methyl is colorless crystals.
01 · Identification
What Thiophanate-Methyl is
Thiophanate-Methyl is colorless crystals. Its molecular formula is C12H14N4O4S2 and its molecular weight is 342.4 g/mol. It melts at 172 °C.
Under the GHS it carries the signal word Warning.
02 · Identifiers
Thiophanate-Methyl identifiers and molecular data
Thiophanate-Methyl CAS number and EC number
Thiophanate-Methyl molecular formula and molecular weight
Other names for Thiophanate-Methyl
- thiophanate-methyl (ISO)
- dimethyl (1,2-phenylenedicarbamo-thioyl)biscarbamate
- dimethyl 4,4′-(o-phenylene) bis(3-thioallophanate)
03 · GHS classification
Thiophanate-Methyl hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Thiophanate-Methyl pictograms and signal word
Thiophanate-Methyl hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - inhalation GHS chapter 3.1 | Category 4 | H332 | GHS07 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Germ cell mutagenicity GHS chapter 3.5 | Category 2 | H341 | GHS08 |
| Carcinogenicity GHS chapter 3.6 | Category 2 | H351 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Thiophanate-Methyl hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H351 | Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H341 | Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H332 | Harmful if inhaled. |
| H317 | May cause an allergic skin reaction. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Thiophanate-Methyl. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Thiophanate-Methyl
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Thiophanate-Methyl issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Thiophanate-Methyl precautionary statements
CLP Annex VI assigns 14 precautionary statements to Thiophanate-Methyl. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Thiophanate-Methyl name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | тиофанат-метил (ISO) диметилов (1,2-фенилендикарбамотиоил)бискарбаматдиметилов 4,4′-( o -фенилен)бис(3-тиоалофанат) |
| Spanish español | Tiofanato-metilo (ISO) (1,2-fenilendicarbamotioil)biscarbamato de dimetilo4,4′-( o -fenilen)bis(3-tioalofanato) de dimetilo |
| Czech čeština | thiofanát-methyl (ISO) dimethyl (1,2-fenylendikarbamothioyl)dikarbamátdimethyl 4,4′-( o -fenylen)bis(3-thioallofanát) |
| Danish dansk | thiophanatmethyl (ISO) dimethyl (1,2-phenylendicarbamothioyl)biscarbamatdimethyl-4,4′-( o -phenylen)bis(3-thioallophanat) |
| German Deutsch | Thiophanat-methyl (ISO) Dimethyl-(1,2-phenylendicarbamothioyl)biscarbamatDimethyl-4,4’-( o -phenylen)bis(3-thioallophanat) |
| Estonian eesti | metüültiofanaat (ISO) dimetüül-(1,2-fenüleendikarbamotioüül)biskarbamaatdimetüül 4,4′-( o -fenüleen)bis(3-tioallofanaat) |
| Greek ελληνικά | thiophanate-methyl (θειοφανικό μεθύλιο) (ISO) (1,2-φαινυλενοδικαρβαμοθειοϋλο)δικαρβαμιδικό διμεθύλιο4,4′-(ο-φαινυλενο)-δις(3-θειοαλλοφανικό) διμεθύλιο |
| English English | thiophanate-methyl (ISO) dimethyl (1,2-phenylenedicarbamothioyl)biscarbamatedimethyl 4,4′-( o -phenylene)bis(3-thioallophanate) |
| French français | thiophanate-méthyle (ISO) (1,2-phénylènedicarbamothioyl)biscarbamate de diméthyle4,4′-( o -phénylène)bis(3-thioallophanate) de diméthyle |
| Croatian hrvatski | tiofanat-metil (ISO) dimetil (1,2-fenilenedikarbamotioil)biskarbamatdimetil 4,4′-( o -fenilen)bis(3-tioalofanat) |
| Italian italiano | tiofanato-metile (ISO) biscarbammato di dimetil (1,2-fenilenedicarbamotioil)dimetil 4,4’-(o-fenilene)bis(3-tioallofanato) |
| Latvian latviešu | tiofanātmetils (ISO) dimetil(1,2-fenilēndikarbamotioil)biskarbamātsdimetil-4,4′-( o -fenilēn)bis(3-tioalofanāts) |
| Lithuanian lietuvių | metiltiofanatas (ISO) dimetilo (1,2-fenilendikarbamotioil)biskarbamatasdimetilo 4,4′-(o-fenilen)bis(3-tioalofanatas) |
| Hungarian magyar | tiofanát-metil (ISO) dimetil-(1,2-feniléndikarbamotioil)biszkarbamátdimetil 4,4′-( o -fenilén)bisz(3-tioallofanát) |
| Maltese Malti | tijofanat-metil (ISO) dimetil (1,2-fenilendikarbamotijoil)biskarbamatdimetil 4,4’-( o -fenilen)bis(3-tijoallofanat) |
| Dutch Nederlands | thiofanaat-methyl (ISO) dimethyl(1,2-fenyleendicarbamothioyl)biscarbamaatdimethyl 4,4′-( o -fenyleen)bis(3-thioallofanaat) |
| Polish polski | tiofanat metylu (ISO) (1,2-fenylenodikarbamotioilo)biskarbaminian dimetyludimetylo-4,4′-( o -fenyleno)bis(3-tioallofanat) |
| Portuguese português | tiofanato-metilo (ISO) (1,2-fenilenodicarbamotioil)biscarbamato de dimetilo4,4′-( o -fenileno)bis(3-tioalofanato) de dimetilo |
| Romanian română | tiofanat-metil (ISO) (1,2-fenilendicarbotitioil) biscarbamat de dimetil4,4′-( o -fenilen)bis(3-tioalofanat) de dimetil |
| Slovak slovenčina | metyl-tiofanát (ISO), O , O -dimetyl-(1,2-fenyléndikarbamotioyl)biskarbamát, 1,2-bis[3-(metoxykarbonyl)tioureido]benzén |
| Slovenian slovenščina | tiofanat-metil (ISO) dimetil (1,2-fenilendikarbamotioil)biskarbamatdimetil 4,4′-( o -fenilen)bis(3-tioalofanat) |
| Finnish suomi | tiofanaatti-metyyli (ISO) dimetyyli (1,2-fenyleenidikarbamotioyyli)biskarbamaattidimetyyli 4,4′-( o -fenyleeni)bis(3-tioallofanaatti) |
| Swedish svenska | tiofanatmetyl (ISO) dimetyl-(1,2-fenylendikarbamotioyl)biskarbamatdimetyl-4,4′-( o -fenylen)bis(3-tioallofanat) |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Thiophanate-Methyl GHS label elements
Everything CLP Annex VI fixes for Thiophanate-Methyl, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Thiophanate-Methyl
- Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful if inhaled.
- May cause an allergic skin reaction.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Use only outdoors or in a well-ventilated area.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF INHALED:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- If skin irritation or rash occurs:
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Thiophanate-Methyl in the GHS label constructor →
07 · Health hazards
Thiophanate-Methyl health hazards and exposure limits
Thiophanate-Methyl hazard summary
Mildly irritating to skin and eyes; Does not inhibit the cholinesterase enzyme; Effects in high-dose animal studies include convulsions; In chronic feeding studies of mice, thyroxin (T4) levels were low, and TSH levels were high; Causes developmental and reproductive effects at maternotoxic doses; [HSDB] May cause irritation; [CAMEO] May cause skin sensitization; [eChemPortal: ESIS] A skin sensitizer in animal testing; [Reference #1]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Thiophanate-Methyl carcinogenicity classification
Cancer Classification: Likely to be Carcinogenic to Humans
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Thiophanate-Methyl properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Thiophanate-Methyl melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 172.22 °C (342 °F) | OSHA | |
| 182 °C (359.6 °F) | range, midpoint shown | HSDB | |
| 172 °C (341.6 °F) | decomposes, decomposes | HSDB |
Thiophanate-Methyl solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Thiophanate methyl is slightly soluble in most organic solvents... . | HSDB | |
| In acetone 58.1, cyclohexanone 43, methanol 29.2, acetonitrile 24.4, ethyl acetate 11.9 (all in g/kg, 23 °C). Slightly soluble in hexane. | at 23 °C | HSDB |
Thiophanate-Methyl vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 7.13e-8 mmHg | at 25 °C | HSDB |
| 1e-7 mmHg | below this value | OSHA | |
| 1e-7 mmHg | below this value, at 20 °C | CAMEO |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Source notes
Further notes on Thiophanate-Methyl
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Solubility
Sparingly soluble in most organic solvents at 25 °C (2.9 g/100 mL acetone; 7.8X10-1 g/100 mL methanol; 8.4X10-1 g/100 mL ethyl acetate; 7.3X10-2 g/100 mL dichloromethane; 1.8X10-2 g/100 mL n-octanol; 1.1X10-2 g/100 mL xylene; and 4.7X10-5 g/100 mL n-hexane)
Source: HSDB
10 · Handling and storage
Thiophanate-Methyl storage and handling
Thiophanate-Methyl incompatible materials
... Incompatible with alkaline & copper-containing compounds.
Source: Hazardous Substances Data Bank (HSDB)
Thiophanate-Methyl reactivity
THIOPHANATE-METHYL is incompatible with strong acids and bases, and with strong reducing agents such as hydrides. Produces flammable gaseous hydrogen with active metals or nitrides. Incompatible with strong oxidizing acids, peroxides. Incompatible with alkaline material. Forms complexes with copper salts (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Thiophanate-Methyl in the storage compatibility matrix →
11 · Questions
Thiophanate-Methyl — frequently asked questions
What is the CAS number of Thiophanate-Methyl?
The CAS number of Thiophanate-Methyl is 23564-05-8. Its EC number is 245-740-7.
What is the chemical formula of Thiophanate-Methyl?
The molecular formula of Thiophanate-Methyl is C12H14N4O4S2 and its molecular weight is 342.4 g/mol.
What does a Thiophanate-Methyl label have to show?
Under CLP Annex VI the label for Thiophanate-Methyl carries the pictograms Health hazard, Exclamation mark and Environment and the signal word is Warning.
Is Thiophanate-Methyl flammable?
CLP Annex VI assigns Thiophanate-Methyl no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Thiophanate-Methyl a carcinogen?
CLP Annex VI assigns Thiophanate-Methyl H351 — suspected of causing cancer. That is category 2: the evidence points that way but is not conclusive.
What is the melting point of Thiophanate-Methyl?
The melting point reported for Thiophanate-Methyl is 172.22 °C (342 °F) (OSHA).
Nearby
Substances next to Thiophanate-Methyl
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