Substance profile
4-Chloroaniline
4-Chloroaniline is orthorhombic crystals from alcohol or petroleum ether with a slightly sweetish; characteristic amine odor.
01 · Identification
What 4-Chloroaniline is
4-Chloroaniline is orthorhombic crystals from alcohol or petroleum ether with a slightly sweetish; characteristic amine odor. Its molecular formula is C6H6ClN and its molecular weight is 127.57 g/mol. It boils at 232 °C, melts at 72.5 °C.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
4-Chloroaniline identifiers and molecular data
4-Chloroaniline CAS number and EC number
4-Chloroaniline molecular formula and molecular weight
03 · GHS classification
4-Chloroaniline hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
4-Chloroaniline pictograms and signal word
4-Chloroaniline hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 3 | H331 | GHS06 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
4-Chloroaniline hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H331 | Toxic if inhaled. |
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
| H317 | May cause an allergic skin reaction. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 4-Chloroaniline. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 4-Chloroaniline
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 4-Chloroaniline issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
4-Chloroaniline precautionary statements
CLP Annex VI assigns 19 precautionary statements to 4-Chloroaniline. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
4-Chloroaniline name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 4-хлороанилин |
| Spanish español | 4-Cloroanilina |
| Czech čeština | 4-chloranilin |
| Danish dansk | 4-chloranilin |
| German Deutsch | 4-Chloranilin |
| Estonian eesti | 4-kloroaniliin |
| Greek ελληνικά | 4-χλωροανιλίνη |
| English English | 4-chloroaniline |
| French français | 4-chloroaniline |
| Croatian hrvatski | 4-kloranilin |
| Italian italiano | 4-cloroanilina |
| Latvian latviešu | 4-hloranilīns |
| Lithuanian lietuvių | 4-chloranilinas |
| Hungarian magyar | 4-klóranilin |
| Maltese Malti | 4-kloroanilina |
| Dutch Nederlands | 4-chlooraniline |
| Polish polski | 4-chloroanilina |
| Portuguese português | 4-cloroanilina |
| Romanian română | 4-cloroanilină |
| Slovak slovenčina | 4-chlóranilín |
| Slovenian slovenščina | 4-kloroanilin |
| Finnish suomi | 4-kloorianiliini |
| Swedish svenska | 4-kloranilin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
4-Chloroaniline GHS label elements
Everything CLP Annex VI fixes for 4-Chloroaniline, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
4-Chloroaniline
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Toxic if inhaled.
- Toxic in contact with skin.
- Toxic if swallowed.
- May cause an allergic skin reaction.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF exposed or concerned:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation or rash occurs:
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 4-Chloroaniline in the GHS label constructor →
07 · Health hazards
4-Chloroaniline health hazards and exposure limits
4-Chloroaniline hazard summary
An eye irritant; Inhalation of high concentrations can cause methemoglobinemia; [ICSC] Toxic by ingestion, inhalation, or skin absorption; [CAMEO] May be a skin sensitizer based on animal studies; [CHEMINFO] May cause skin sensitization; [eChemPortal: ESIS] In the past, cases of severe methemoglobinemia were reported in workers manufacturing this chemical; Evidence of liver and kidney injury in high-dose animal experiments; 3-15% methemoglobin levels induced in rats at a dose of 13-40 mg/kg; [HSDB] An irritant; May cause skin sensitization; Effects in high-dose animal studies include convulsions, methemoglobinemia, and cyanosis; [MSDSonline] Danger of cutaneous absorption; Danger of skin sensitization; [MAK]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
4-Chloroaniline carcinogenicity classification
Studied by the US National Toxicology Program: TR-189: Bioassay of p-Chloroaniline for Possible Carcinogenicity (CASRN 106-47-8) (1979 )
Cancer Classification: Group B2 Probable Human Carcinogen
Source: Hazardous Substances Data Bank (HSDB)
Evaluation: There is inadequate evidence in humans for the carcinogenicty of para-chloroaniline. There is sufficient evidence in experimental animals for the carcinogenicity of para-chloroaniline. OVERALL EVALUATION: Group 2B: para-Chloroaniline is possibly carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
4-Chloroaniline properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
4-Chloroaniline boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 232 °C (449.6 °F) | HSDB | |
| 232.22 °C (450 °F) | at 760 mmHg | CAMEO |
4-Chloroaniline melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 72.5 °C (162.5 °F) | HSDB |
4-Chloroaniline density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.4 g/cm³ | ICSC | |
| 1.43 g/cm³ | at 19 °C | CAMEO |
4-Chloroaniline solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Freely soluble in alcohol, ether, acetone, carbon disulfide | HSDB | |
| less than 1 mg/mL at 74.3 °F (NTP, 1992) | at 23.5 °C | CAMEO | |
| In water, 3,900 mg/L at 25 °C | at 25 °C | HSDB |
4-Chloroaniline vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.015 mmHg | at 20 °C | CAMEO |
| 0.071 mmHg | at 25 °C | HSDB |
4-Chloroaniline flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 112.78 °C (235 °F) | CAMEO | |
| 121.5 °C (250.7 °F) | range, midpoint shown | ICSC |
4-Chloroaniline autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 685 °C (1265 °F) | ICSC |
4-Chloroaniline lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 2.2 % by volume | CAMEO |
4-Chloroaniline vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4.41 (air = 1) | CAMEO | |
| 4.4 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
4-Chloroaniline storage and handling
4-Chloroaniline safe storage
Separated from strong oxidants and food and feedstuffs.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
4-Chloroaniline storage conditions
Storage temperature: ambient.
Source: Hazardous Substances Data Bank (HSDB)
4-Chloroaniline incompatible materials
Very vigorous reactions may occur with strong oxidants.
Source: Hazardous Substances Data Bank (HSDB)
4-Chloroaniline reactivity
P-CHLOROANILINE is incompatible with oxidizing agents. Also incompatible with acids, acid chlorides, acid anhydrides and chloroformates. Subject to exothermic decomposition during high-temperature distillation. Incompatible with nitrous acid. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4-Chloroaniline in the storage compatibility matrix →
10 · Questions
4-Chloroaniline — frequently asked questions
What is the CAS number of 4-Chloroaniline?
The CAS number of 4-Chloroaniline is 106-47-8. Its EC number is 203-401-0.
What is the chemical formula of 4-Chloroaniline?
The molecular formula of 4-Chloroaniline is C6H6ClN and its molecular weight is 127.57 g/mol.
What does a 4-Chloroaniline label have to show?
Under CLP Annex VI the label for 4-Chloroaniline carries the pictograms Skull and crossbones, Health hazard and Environment and the signal word is Danger.
Is 4-Chloroaniline flammable?
CLP Annex VI assigns 4-Chloroaniline no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 112.78 °C (235 °F) (CAMEO).
Is 4-Chloroaniline a carcinogen?
Yes. CLP Annex VI classifies 4-Chloroaniline as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of 4-Chloroaniline?
The boiling point reported for 4-Chloroaniline is 232 °C (449.6 °F) (HSDB).
What is the melting point of 4-Chloroaniline?
The melting point reported for 4-Chloroaniline is 72.5 °C (162.5 °F) (HSDB).
How should 4-Chloroaniline be stored?
Storage temperature: ambient. (Hazardous Substances Data Bank (HSDB))
Nearby
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