Substance profile
4-methyl-m-phenylenediamine
4-methyl-m-phenylenediamine is needles from water; crystals from alcohol.
01 · Identification
What 4-methyl-m-phenylenediamine is
4-methyl-m-phenylenediamine is needles from water; crystals from alcohol. Its molecular formula is C7H10N2 and its molecular weight is 122.17 g/mol. It boils at 292 °C, melts at 99 °C, is soluble in water.
Under the GHS it carries the signal word Danger. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
4-methyl-m-phenylenediamine identifiers and molecular data
4-methyl-m-phenylenediamine CAS number and EC number
4-methyl-m-phenylenediamine molecular formula and molecular weight
Other names for 4-methyl-m-phenylenediamine
- 2,4-toluenediamine
03 · GHS classification
4-methyl-m-phenylenediamine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
4-methyl-m-phenylenediamine pictograms and signal word
4-methyl-m-phenylenediamine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 4 | H312 | GHS07 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Germ cell mutagenicity GHS chapter 3.5 | Category 2 | H341 | GHS08 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 2 | H373 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 2 | H411 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
4-methyl-m-phenylenediamine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H341 | Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H361f | Suspected of damaging fertility. |
| H301 | Toxic if swallowed. |
| H312 | Harmful in contact with skin. |
| H373 | May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H317 | May cause an allergic skin reaction. |
| H411 | Toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 4-methyl-m-phenylenediamin…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 4-methyl-m-phenylenediamin…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 4-methyl-m-phenylenedi… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
4-methyl-m-phenylenediamine precautionary statements
CLP Annex VI assigns 19 precautionary statements to 4-methyl-m-phenylenediamin…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
4-methyl-m-phenylenediamine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 4-метил- m -фенилендиамин 2,4-толуендиамин |
| Spanish español | 4-Metil- m -fenilendiamina 2,4-toluenodiamina |
| Czech čeština | 4-methyl-1,3-fenylendiamin 4-methylbenzen-1,3-diamin |
| Danish dansk | 4-methyl- m -phenylendiamin 2,4-toluendiamin |
| German Deutsch | 4-Methyl-m-phenylendiamin 2,4-Toluylendiamin2,4-Diaminotoluol |
| Estonian eesti | 4-metüül- m -fenüleendiamiin 2,4-tolueendiamiin |
| Greek ελληνικά | 4-μεθυλο- m -φαινυλενοδιαμίνη τολουολοδιαμίνη-2,4 |
| English English | 4-methyl- m -phenylenediamine 2,4-toluenediamine |
| French français | 4-méthyl- m -phénylènediamine 2,4-toluènediamine |
| Croatian hrvatski | 4-metil- m -fenilenediamin 2,4-toluendiamin |
| Italian italiano | 4-metil- m -fenilendiammina 2,4-diamminotoluene |
| Latvian latviešu | 4-metil- m -fenilēndiamīns 2,4-toluoldiamīns |
| Lithuanian lietuvių | 4-metil- m -fenilendiaminas 2,4-toluendiaminas |
| Hungarian magyar | 4-metil- m -feniléndiamin 2,4-toluoldiamin |
| Maltese Malti | 4-metil- m -fenilendiammina 2,4-toluwendiammina |
| Dutch Nederlands | 4-methyl- m -fenyleendiamine 2,4-tolueendiamine |
| Polish polski | 4-metylo- m -fenylenodiamina 4-metylo-1,3-fenylenodiaminatolueno-2,4-diamina |
| Portuguese português | 4-metil- m -fenilenodiamina 2,4-toluenodiamina |
| Romanian română | 4-metil- m -fenilendiamină 2,4-toluendiamină |
| Slovak slovenčina | 4-metyl-1,3-fenyléndiamín 4-metylbenzén-1,3-diamín |
| Slovenian slovenščina | 4-metil- m -fenilendiamin 2,4-toluendiamin |
| Finnish suomi | 4-metyyli- m -fenyleenidiamiini 2,4-tolueenidiamiini |
| Swedish svenska | 4-metyl- m -fenylendiamin 2,4-toluendiamin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
4-methyl-m-phenylenediamine GHS label elements
Everything CLP Annex VI fixes for 4-methyl-m-phenylenediamin…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
4-methyl-m-phenylenediamine
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Suspected of damaging fertility.
- Toxic if swallowed.
- Harmful in contact with skin.
- May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May cause an allergic skin reaction.
- Toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF exposed or concerned:
- Immediately call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Get medical advice/attention if you feel unwell.
- Rinse mouth.
- If skin irritation or rash occurs:
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 4-methyl-m-phenylenediamin… in the GHS label constructor →
07 · Health hazards
4-methyl-m-phenylenediamine health hazards and exposure limits
4-methyl-m-phenylenediamine hazard summary
Exposure to toluene-2,4-diamine is primarily occupational. Acute (short-term) exposure to high levels of toluene-2,4-diamine in humans has caused severe skin and eye irritation sometimes leading to permanent blindness. Other effects include respiratory problems, stomach gas, rise in blood pressure, dizziness, convulsions, fainting, and coma. No information is available regarding the chronic (long-term) or carcinogenic effects of toluene-2,4-diamine in humans. Chronic animal studies have reported liver injury. In animal studies, toluene-2,4-diamine was carcinogenic following dietary administration, producing a significant increase in the incidence of a large variety of tumor types, including liver, mammary gland, subcutaneous fibromas, lung lymphomas, and leukemia. EPA has classified toluene-2,4-diamine as a Group B2, probable human carcinogen.
Source: EPA Hazardous Air Pollutants
4-methyl-m-phenylenediamine carcinogenicity classification
Under the conditions of this bioassay, 2,4-diaminotoluene was carcinogenic for F344 rats, inducing hepatocellular carcinomas or neoplastic nodules in both males and females and carcinomas or adenomas of the mammary gland in females. The test chemical was also carcinogenic for female B6C3F1 mice, inducing hepatocellular carcinomas. The incidence of lymphomas in the female mice suggested that these tumors may also have been related to administration of the test chemical.
Source: US National Toxicology Program · TR-162: Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity (CASRN 95-80-7) (1979 )
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
2,4-Diaminotoluene: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
4-methyl-m-phenylenediamine occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | none | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | Ca (all isomers) See Appendix A | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | A potential occupational carcinogen. (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | NIOSH considers toluenediamine to be a potential occupational carcinogen. /Toluenediamine/ | Hazardous Substances Data Bank (HSDB) |
| IDLH | Ca [N.D.] | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
4-methyl-m-phenylenediamine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
4-methyl-m-phenylenediamine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 292 °C (557.6 °F) | HSDB | |
| 292.22 °C (558 °F) | NIOSH | ||
| 292.22 °C (558 °F) | at 760 mmHg | CAMEO |
4-methyl-m-phenylenediamine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 99 °C (210.2 °F) | HSDB | |
| 98.89 °C (210 °F) | NIOSH |
4-methyl-m-phenylenediamine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.26 g/cm³ | ICSC | |
| 1.05 g/cm³ | at 100 °C | NIOSH | |
| 1.045 g/cm³ | at 100 °C | CAMEO |
4-methyl-m-phenylenediamine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Very soluble in water, ethanol, ethyl ether; soluble in acetone, carbon disulfide | HSDB | |
| Soluble in water, alcohol, and ether | HSDB | ||
| Soluble | NIOSH |
4-methyl-m-phenylenediamine vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.00017 mmHg | at 25 °C | HSDB |
| 1 mmHg | at 106.5 °C | HSDB | |
| 1 mmHg | at 106.67 °C | NIOSH |
4-methyl-m-phenylenediamine flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 149 °C (300.2 °F) | HSDB | |
| 148.89 °C (300 °F) | NIOSH |
4-methyl-m-phenylenediamine autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 475 °C (887 °F) | ICSC |
4-methyl-m-phenylenediamine lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Combustible Solid | NIOSH |
4-methyl-m-phenylenediamine vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4.2 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
4-methyl-m-phenylenediamine storage and handling
4-methyl-m-phenylenediamine safe storage
Well closed. Separated from oxidants and acids. Separated from food and feedstuffs. Store in an area without drain or sewer access. Do NOT store or transport in containers made from aluminium or copper and its alloys. Provision to contain effluent from fire extinguishing.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
4-methyl-m-phenylenediamine storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
4-methyl-m-phenylenediamine incompatible materials
None reported
Source: The National Institute for Occupational Safety and Health (NIOSH)
4-methyl-m-phenylenediamine reactivity
2,4-TOLUENEDIAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts vigorously with oxidizing agents (USCG, 1999).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4-methyl-m-phenylenediami… in the storage compatibility matrix →
10 · Questions
4-methyl-m-phenylenediamine — frequently asked questions
What is the CAS number of 4-methyl-m-phenylenediamine?
The CAS number of 4-methyl-m-phenylenediamine is 95-80-7. Its EC number is 202-453-1.
What is the chemical formula of 4-methyl-m-phenylenediamine?
The molecular formula of 4-methyl-m-phenylenediamine is C7H10N2 and its molecular weight is 122.17 g/mol.
What does a 4-methyl-m-phenylenediamine label have to show?
Under CLP Annex VI the label for 4-methyl-m-phenylenediamine carries the pictograms Skull and crossbones, Health hazard and Environment and the signal word is Danger.
Is 4-methyl-m-phenylenediamine flammable?
CLP Annex VI assigns 4-methyl-m-phenylenediamine no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 149 °C (300.2 °F) (HSDB).
Is 4-methyl-m-phenylenediamine a carcinogen?
Yes. CLP Annex VI classifies 4-methyl-m-phenylenediamine as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the exposure limit for 4-methyl-m-phenylenediamine?
The US occupational exposure limit reported for 4-methyl-m-phenylenediamine is none (The National Institute for Occupational Safety and Health (NIOSH)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of 4-methyl-m-phenylenediamine?
The boiling point reported for 4-methyl-m-phenylenediamine is 292 °C (557.6 °F) (HSDB).
What is the melting point of 4-methyl-m-phenylenediamine?
The melting point reported for 4-methyl-m-phenylenediamine is 99 °C (210.2 °F) (HSDB).
How should 4-methyl-m-phenylenediamine be stored?
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ (Hazardous Substances Data Bank (HSDB))
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