Substance profile
Diphenylamine
Diphenylamine is monoclinic leaflets from dilute alcohol with a pleasant, floral odor.
01 · Identification
What Diphenylamine is
Diphenylamine is monoclinic leaflets from dilute alcohol with a pleasant, floral odor. Its molecular formula is C12H11N and its molecular weight is 169.22 g/mol. It boils at 302 °C, melts at 52.8 °C, is soluble in water.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Diphenylamine identifiers and molecular data
Diphenylamine CAS number and EC number
Diphenylamine molecular formula and molecular weight
03 · GHS classification
Diphenylamine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Diphenylamine pictograms and signal word
Diphenylamine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 3 | H331 | GHS06 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 2 | H373 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Diphenylamine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H331 | Toxic if inhaled. |
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
| H373 | May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Diphenylamine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Diphenylamine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Diphenylamine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Diphenylamine precautionary statements
CLP Annex VI assigns 14 precautionary statements to Diphenylamine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Diphenylamine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | дифениламин |
| Spanish español | Difenilamina |
| Czech čeština | difenylamin |
| Danish dansk | diphenylamin |
| German Deutsch | Diphenylamin |
| Estonian eesti | difenüülamiin |
| Greek ελληνικά | διφαινυλαμίνη |
| English English | diphenylamine |
| French français | diphénylamine |
| Croatian hrvatski | difenilamin |
| Italian italiano | difenilamina |
| Latvian latviešu | difenilamīns |
| Lithuanian lietuvių | difenilaminas |
| Hungarian magyar | difenilamin |
| Maltese Malti | difenilammina |
| Dutch Nederlands | difenylamine |
| Polish polski | difenyloamina |
| Portuguese português | difenilamina |
| Romanian română | difenilamină |
| Slovak slovenčina | difenylamín |
| Slovenian slovenščina | difenilamin |
| Finnish suomi | difenyyliamiini |
| Swedish svenska | difenylamin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Diphenylamine GHS label elements
Everything CLP Annex VI fixes for Diphenylamine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Diphenylamine
- Toxic if inhaled.
- Toxic in contact with skin.
- Toxic if swallowed.
- May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention if you feel unwell.
- Rinse mouth.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Diphenylamine in the GHS label constructor →
07 · Health hazards
Diphenylamine health hazards and exposure limits
Diphenylamine hazard summary
The toxicity of diphenylamine is similar to that of aniline. Hepatotoxic effects have been demonstrated in animals. It can cause bladder irritation and induce methemoglobinemia in workers. As a skin sensitizer it cross-reacts with p-phenylene diamine. [ACGIH] May have effects on the kidneys and blood; A skin, eye, and respiratory tract irritant; [ICSC]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Diphenylamine carcinogenicity classification
Cancer Classification: Not Likely to be Carcinogenic to Humans
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
Diphenylamine occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 10 mg/m³ (Construction and Maritime only) | Occupational Safety and Health Administration (OSHA) |
| PEL | none See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 10 mg/m³ | Occupational Safety and Health Administration (OSHA) |
| REL | TWA 10 mg/m3 | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | N.D. | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Diphenylamine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Diphenylamine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 302 °C (575.6 °F) | HSDB | |
| 302.22 °C (576 °F) | NIOSH | ||
| 302.22 °C (576 °F) | at 760 mmHg | CAMEO |
Diphenylamine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 52.78 °C (127 °F) | NIOSH | |
| 53 °C (127.4 °F) | ICSC |
Diphenylamine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.16 g/cm³ | HSDB | |
| 1.2 g/cm³ | ICSC |
Diphenylamine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | 1 g dissolves in 2.2 ml of alcohol, 4 ml propyl alcohol; Freely sol in benzene, ether, glacial acetic acid, carbon disulfide. | HSDB | |
| Very sol in ethanol, acetone, benzene, carbon tetrachloride, pyridine, ethyl acetate; sol in ether, acetic acid; slightly sol in chloroform | HSDB | ||
| Soluble in oxygenated and aromatic solvents | HSDB |
Diphenylamine vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.00067 mmHg | at 25 °C | HSDB |
| 1 mmHg | at 108.33 °C | NIOSH | |
| 1 mmHg | at 108.28 °C | CAMEO |
Diphenylamine flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 153 °C (307.4 °F) | HSDB | |
| 152.78 °C (307 °F) | NIOSH |
Diphenylamine autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 633.89 °C (1173 °F) | HSDB | |
| 635 °C (1175 °F) | CAMEO | ||
| 634 °C (1173.2 °F) | ICSC |
Diphenylamine lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Dust may be explosive if mixed with air in critical proportions and in presence of a source of ignition. | HSDB | |
| Combustible Solid; explosive if a cloud of dust is exposed to a source of ignition. | NIOSH |
Diphenylamine vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 5.82 (air = 1) | HSDB | |
| 5.8 (air = 1) | ICSC |
Diphenylamine odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | Odor perception threshold is 0.05 mg/L. | HSDB | |
| Odor Threshold Low: 0.02 [mg/m3] | Haz-Map | ||
| Odor threshold from AIHA | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Diphenylamine fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Diphenylamine fire potential
Combustible when exposed to heat or flame.
Source: Hazardous Substances Data Bank (HSDB)
Fire and explosion
...Diphenylamine /added to/...hexachloromelamine would explode if the amt were large and confined. Trichloromelamine behaves similarly...but with more flame and fume production.
Source: HSDB
10 · Handling and storage
Diphenylamine storage and handling
Diphenylamine safe storage
Provision to contain effluent from fire extinguishing. Separated from strong acids and oxidants. Store in an area without drain or sewer access.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Diphenylamine storage conditions
In general, materials which are toxic as stored or which can decompose into toxic components...should be stored in a cool, well-ventilated place, out of direct rays of the sun, away from areas of high fire hazard, and should be periodically inspected... Incompatible materials should be isolated from each other.
Source: Hazardous Substances Data Bank (HSDB)
Diphenylamine incompatible materials
Can react with oxidizing materials
Source: Hazardous Substances Data Bank (HSDB)
Diphenylamine reactivity
DIPHENYLAMINE discolors in light. This chemical can react violently with hexachloromelamine and trichloromelamine. It is incompatible with strong oxidizing agents and strong acids. It is also incompatible with iron and silver salts. It reacts with nitrogen oxides. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Diphenylamine in the storage compatibility matrix →
11 · Questions
Diphenylamine — frequently asked questions
What is the CAS number of Diphenylamine?
The CAS number of Diphenylamine is 122-39-4. Its EC number is 204-539-4.
What is the chemical formula of Diphenylamine?
The molecular formula of Diphenylamine is C12H11N and its molecular weight is 169.22 g/mol.
What does a Diphenylamine label have to show?
Under CLP Annex VI the label for Diphenylamine carries the pictograms Skull and crossbones, Health hazard and Environment and the signal word is Danger.
Is Diphenylamine flammable?
CLP Annex VI assigns Diphenylamine no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 153 °C (307.4 °F) (HSDB).
Is Diphenylamine a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Diphenylamine. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the exposure limit for Diphenylamine?
The US occupational exposure limit reported for Diphenylamine is 10 mg/m³ (Construction and Maritime only) (Occupational Safety and Health Administration (OSHA)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Diphenylamine?
The boiling point reported for Diphenylamine is 302 °C (575.6 °F) (HSDB).
What is the melting point of Diphenylamine?
The melting point reported for Diphenylamine is 52.78 °C (127 °F) (NIOSH).
How should Diphenylamine be stored?
In general, materials which are toxic as stored or which can decompose into toxic components...should be stored in a cool, well-ventilated place, out of direct rays of the sun, away from areas of high fire hazard, and should be periodically inspected... Incompatible materials should be isolated from each other. (Hazardous Substances Data Bank (HSDB))
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